Identifiers
HUGO:RAC1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000
Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1
HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CELL_CELL_ADHESIONS 
 EMT Senescence   / TIGHT_JUNCTIONS 
 EMT Senescence   / CYTOSKELETON_POLARITY 
 EMT Senescence   / LYSOSOME_ENDOSOME 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 
 Regulated Cell Death   / NECROPTOSIS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 
 Survival   / HEDGEHOG 
 Survival   / PI3K_AKT_MTOR 
 Survival   / WNT_NON_CANONICAL 

References
PMID:11756498
PMID:27331412
Methuosis is a caspase-independent cell death accompanied by vacuolization of macropinosomes resulting from dysregulation of macropinocytosis.
Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2).
PMID:11274345
PMID:18000759
PMID:19151919

References
su_mpk1_mpk1_re150( Survival  ):
Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2).
PMID:11274345

References
s_wnc1_re122:( Survival  ) PMID:12514131

1. RAC1@Cytoplasm
2. RAC1@Cytoplasm

1. RAC1@Cytosol

1. RAC1@Plasma Membrane

1. GTP:​RAC1@Cytoplasm
2. POSH*:​RAC1@Cytoplasm
3. GTP:​PLC-_beta_*:​RAC1@Cytoplasm
4. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm
5. GRB2:​MAP3K10_11*|​pho:​RAC1|​pho:​RTK*:​SOS*@Cytoplasm
6. MAPKAP1:​MLST8:​MTOR:​PROTOR*:​RAC1:​RICTOR@Cytoplasm

1. GDP:​RAC1@Cytosol
2. GTP:​RAC1@Cytosol

1. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome

1. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft
2. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft
3. DEPTOR:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft
4. 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft

1. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
2. MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
3. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
4. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
5. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
6. DEPTOR:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
7. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
8. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
9. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome

1. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane

1. GNAI1:​GTP@Cytosol + GDP:​RAC1@Cytosol → GTP:​RAC1@Cytosol + GDP:​GNAI1@Cytosol
2. GNAI2:​GTP@Cytosol + GDP:​RAC1@Cytosol → GTP:​RAC1@Cytosol + GDP:​GNAI2@Cytosol
3. rRAC1@Nucleus → RAC1@Cytosol
4. RAC1@Cytosol → GTP:​RAC1@Cytosol
5. GDP:​RAC1@Cytosol → GTP:​RAC1@Cytosol
6. GTP:​RAC1@Cytosol → GDP:​RAC1@Cytosol
7. GTP:​RAC1@Cytosol → ARHGEF14*@Cytosol
8. GTP:​RAC1@Cytosol → NCKAP1@Cytosol
9. GTP:​RAC1@Cytosol → CYFIP2@Cytosol
10. GTP:​RAC1@Cytosol + NCK1@Cytosol → em_emtc_emtc_s3001
11. GTP:​RAC1@Cytosol → Membrane spreading@Cytosol
12. GTP:​RAC1@Cytosol + IQGAP1@Cytosol → em_s2321
13. GTP:​RAC1@Cytosol → GDP:​RAC1@Cytosol
14. RAC1@Cytosol → ca_s94
15. RAC1@Cytosol + ca_s1703 → GTP binding protein*@Cytosol
16. PRAS40*@Cytoplasm + MLST8@Cytoplasm + RPTOR@Cytoplasm + MTOR|​pho@Cytoplasm + RAC1@Cytoplasm → MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
17. PRAS40*@Cytoplasm + MLST8@Cytoplasm + RPTOR@Cytoplasm + MTOR@Cytoplasm + RAC1@Cytoplasm → MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm
18. DEPTOR@Cytoplasm + MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft → DEPTOR:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft
19. 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft → 14-3-3*:​MAPKAP1:​MLST8:​MTOR:​PROTOR*:​RICTOR|​T1135_pho@Cytoplasm
20. MAPKAP1:​MLST8:​MTOR:​PROTOR*:​RAC1:​RICTOR@Cytoplasm → MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft
21. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm → MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
22. MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
23. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
24. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
25. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
26. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
27. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome
28. DEPTOR@Cytoplasm → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome + DEPTOR:​MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
29. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → (MLST8:​MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm
30. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft → MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft
31. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft + 14-3-3*@Lipid Raft → 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft
32. GRB2:​RTK*:​SOS*@Plasma Membrane + RAC1@Plasma Membrane → GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane
33. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane → RAC1@Plasma Membrane + GRB2:​RTK*:​SOS*@Plasma Membrane
34. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane + MAP3K10_11*@Cytoplasm → GRB2:​MAP3K10_11*|​pho:​RAC1|​pho:​RTK*:​SOS*@Cytoplasm
35. GDP:​RAC1@Cytosol + GTP@Cytosol → GTP:​RAC1@Cytosol + GDP@Cytosol
36. GTP:​RAC1@Cytosol → EMT@Cytosol
37. RAC1@Cytoplasm + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
38. POSH*:​RAC1@Cytoplasm → JNK pathway@Cytoplasm
39. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → RAC1@Cytoplasm + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
40. RAC1@Cytoplasm + POSH*@Cytoplasm → POSH*:​RAC1@Cytoplasm
41. POSH*:​RAC1@Cytoplasm → STAT3 pathway@Cytoplasm
42. GTP:​RAC1@Cytoplasm + PLC-_beta_*@Cytoplasm → GTP:​PLC-_beta_*:​RAC1@Cytoplasm

1. FAK*@Cytosol → FAK*|​activated@Cytosol
2. LEF1_TCF3_4*@Nucleus + _beta_-Catenin*@Cytosol → LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus
3. PAK*@Cytosol → PAK*|​pho|​active@Cytosol
4. MAP3K7_10_11*@Cytosol → MAP3K7_10_11*@Cytosol
5. PAR6*@Cytosol → PAR6*@Cytosol
6. ARFIP2@Cytosol → ARFIP2@Cytosol
7. PIP5K1*@Cytosol → PIP5K1*@Cytosol
8. BAIAP2@Cytosol → BAIAP2@Cytosol
9. PAK1@Cytosol + NISCH@Nucleus → NISCH:​PAK1@Cytosol
10. E-Cadherin*|​Y_pho@Cytosol → E-Cadherin*|​Y_pho@Caveolin vesicle
11. E-Cadherin*|​Y_pho@Cytosol → E-Cadherin*|​Y_pho@Macropinosome
12. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → E-Cadherin*@Caveolin vesicle
13. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol → E-Cadherin*@Macropinosome
14. ATG13:​FIP200*:​ULK*@Cytoplasm → ATG13|​pho:​FIP200*:​ULK*|​pho@Cytoplasm
15. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft → AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft
16. AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm → AKT1|​T450_pho|​S473_emp|​active@Cytoplasm
17. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
18. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
19. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
20. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome
21. SGK1@Cytoplasm → SGK1|​S442_pho@Cytoplasm
22. MAP2K4@Cytoplasm → MAP2K4|​pho|​pho@Cytoplasm
23. MAP2K7@Cytoplasm → MAP2K7|​pho|​pho@Cytoplasm
24. MEK*@Cytoplasm → MEK*|​pho|​pho@Cytoplasm
25. ATP6V0C_D*@Cytoplasm → ATP6V0C_D*@Endosome
26. ATP6V0C_D*@Cytoplasm → ATP6V0C_D*@Endosome
27. PI4,5-P2@Cytoplasm → DAG@Cytoplasm + IP3@Cytoplasm