Identifiers
NAME:GRB2:SOS*
Identifiers
NAME:GRB2:SOS*
References
su_mpk1_mpk1_re286( Survival ):
Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state.
PMID:17496910
su_mpk1_mpk1_re25( Survival ):
Grb2 is recruited to the plasma membrane by activated RTKs.
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue that forms a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2a in response to growth factor stimulation.
PKC may cause phosphorylation of EGFR leading to a decrease in its activity.
PMID:17496910 PMID:15567848 PMID:11447289 PMID:6321473
su_akt1_s_akt1_re11( Survival ):
PMID:15584861
PMID:10648629
→ RAS activation@Cytoplasm
+ GRB2:SOS*@Cytoplasm + PI3,4,5-P3@Lipid Raft + RTK*@Cytoplasm + GF@default + RAS*@Cytoplasm + GAB1|Y977_pho|Y989_pho@Cytoplasm → GAB1|Y977_pho|Y989_pho:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Lipid Raft
+ RTK*@Plasma Membrane → GRB2:RTK*:SOS*@Plasma Membrane
+ SOS*@Cytoplasm → GRB2:SOS*@Cytoplasm