Protein GAB1 map

Identifiers
GRB2 associated binding protein 1
HUGO:GAB1 hgnc_id:HGNC:4066 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480
HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480
HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 GENECARDS:GAB1 REACTOME:147726 ATLASONC:GC_GAB1 WIKI:GAB1
GRB2-associated binding protein 2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:11447289
FGF-induced tyrosine phosphorylation of Gab1 was detected in lysates from wild-type fibroblasts, tyrosine phosphorylation of Gab1 could not be detected in FRS2??-deficient fibroblasts.
FRS2?? Is Required for Recruitment of PI-3 Kinase via the Docking Protein Gab1.
PMID:11313945
PMID:11940581

GAB1|​pho@Cytosol

References
ca_re278( Cancer Associated Fibroblasts  map ):
PMID:16713974
TLR signaling activates and IFNG inhibits PI3K pathway
PMID:11907067, PMID:15536084
SYK kinaze directly interacts with PI3K(p85) and activates perforin ??granule movement and polarization via PI3K /RAC1/PAK1/MEK??/ERK pathway
PMID:10426994??
Phosphorylated DAP10 directly interacts with regulatory subunit (p85) of PI3K and activates downstream pathway.

GAB1@Cytoplasm

References
su_mpk1_mpk1_re287( Survival  map ):
Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by EGFR or FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway.
PMID:15567848
su_akt1_s_akt1_re145:( Survival  map ) PMID:11313945 PMID:11940581

GAB1|​Y977_pho|​Y989_pho@Cytoplasm

References
s_akt1_re145:( Survival  map ) PMID:11313945 PMID:11940581
s_akt1_re11( Survival  map ):
PMID:15584861
PMID:10648629

Modifications:
In compartment: Cytoplasm
  1. GAB1@Cytoplasm map
  2. GAB1@Cytoplasm map
  3. GAB1|​Y977_pho|​Y989_pho@Cytoplasm map
In compartment: Cytosol
  1. GAB1@Cytosol map
  2. GAB1|​pho@Cytosol map
Participates in complexes:
In compartment: Cytoplasm
  1. GAB1:​GRB2@Cytoplasm map
  2. GAB1|​pho:​GRB2@Cytoplasm map
In compartment: Endosome
  1. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map
In compartment: Lipid Raft
  1. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map
Participates in reactions:
As Reactant or Product:
  1. GAB1@Cytosol map → map GAB1|​pho@Cytosol map
  2. p110*:​p85*@Cytoplasm map + GRB2:​SOS*@Cytoplasm map + PI3,4,5-P3@Lipid Raft map + RTK*@Cytoplasm map + GF@default map + RAS*@Cytoplasm map + GAB1|​Y977_pho|​Y989_pho@Cytoplasm map → map GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map
  3. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map → map Ubiquitination@Cytoplasm map
  4. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map → map GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map
  5. GAB1@Cytoplasm map → map GAB1|​Y977_pho|​Y989_pho@Cytoplasm map
  6. GAB1:​GRB2@Cytoplasm map → map GAB1|​pho:​GRB2@Cytoplasm map
  7. GRB2@Cytoplasm map + GAB1@Cytoplasm map → map GAB1:​GRB2@Cytoplasm map
As Catalyser:
  1. PI3KR(p85)*@Cytosol map → map PI3KR(p85)*@Cytosol map
  2. PtdIns(4,5)-P2@Lipid Raft map → map PI3,4,5-P3@Lipid Raft map
  3. p110*@Cytoplasm map → map p110*|​pho@Cytoplasm map