Complex GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*:SOS*:p110*:p85*
Complex composition:
- GF
- PI3,4,5-P3
- GRB2
- p85*
- p110*
- SOS*
- RAS*
- RTK*
- GAB1
GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Endosome
Identifiers
NAME:GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*:SOS*:p110*:p85*
References
s_akt1_re136( Survival
):
PMID:10514377
PMID:17635922
GAB1|Y977_pho|Y989_pho:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Lipid Raft
Identifiers
NAME:GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*:SOS*:p110*:p85*
References
s_akt1_re11( Survival
):
PMID:15584861
PMID:10648629
s_akt1_re3( Survival
):
PMID:15534002
PMID:9779982
PMID:14585353
Modifications:
Participates in complexes:
In compartment: Endosome
- GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Endosome
In compartment: Lipid Raft
- GAB1|Y977_pho|Y989_pho:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Lipid Raft
Participates in reactions:
As Reactant or Product:- p110*:p85*@Cytoplasm
+ GRB2:SOS*@Cytoplasm
+ PI3,4,5-P3@Lipid Raft
+ RTK*@Cytoplasm
+ GF@default
+ RAS*@Cytoplasm
+ GAB1|Y977_pho|Y989_pho@Cytoplasm
→
GAB1|Y977_pho|Y989_pho:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Lipid Raft
- GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Endosome
→
Ubiquitination@Cytoplasm
- GAB1|Y977_pho|Y989_pho:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Lipid Raft
→
GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*|pho|pho|hm2:SOS*:p110*:p85*@Endosome
As Catalyser:- PtdIns(4,5)-P2@Lipid Raft
→
PI3,4,5-P3@Lipid Raft