GRB2:LAMTOR2:MEK*:MP1*:RAS*:RTK*:SOS*

Complex GRB2:LAMTOR2:MEK*:MP1*:RAS*:RTK*:SOS*

Complex composition:

GRB2:LAMTOR2:MEK*:MP1*:RAS*|pho:RTK*:SOS*@Late Endosomes

Identifiers
NAME:GRB2:LAMTOR2:MEK*:MP1*:RAS*:RTK*:SOS*

References
su_mpk1_mpk1_re19( Survival ):
Transfer of activated RTK/Grb2/Sos/RasGTP complex to late endosomes where it binds P14/MP1/MEK1 complex allowing the ERK cascade.
Upon EGF stimulation EGFR in complex with Grb2 is endocytosed and transported to late endosomes with Grb2-binding proteins such as Sos resulting in the activation of KRas on late endosomes.
PMID:17496910 PMID:19289794
su_mpk1_mpk1_re193( Survival ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:18039929
su_mpk1_mpk1_re21( Survival ):
Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway.
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment.
PMID:19289794 PMID:17496910

Modifications:
Participates in complexes:
In compartment: Late Endosomes

GRB2:LAMTOR2:MEK*:MP1*:RAS*|pho:RTK*:SOS*@Late Endosomes

Participates in reactions:
As Reactant or Product:

As Catalyser: