GRB2:RAS*:RTK*:SOS*

Complex GRB2:RAS*:RTK*:SOS*

Complex composition:

GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane

Identifiers
NAME:GRB2:RAS*:RTK*:SOS*

References
su_mpk1_mpk1_re9( Survival ):
Sos mediates Ras activation. Interaction of Sos with Ras induces the formation of RasGTP from RasGDP.
Spry is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2.
PMID:17496910 PMID:15173823
su_mpk1_mpk1_re103( Survival ):
BCL2 protein can target Raf-1 (C-Raf) to mitochondria.
PMID:8929532
su_mpk1_mpk1_re13( Survival ):
B-Raf is recruited on the plasma membrane by activated Ras.
Activated Ras functions as an adapter that binds to Raf kinases with high a???nity and causes their translocation to the cell membrane where Raf activation takes place.
RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment.
PMID:19541618 PMID:11023813 PMID:17496910
su_mpk1_mpk1_re19( Survival ):
Transfer of activated RTK/Grb2/Sos/RasGTP complex to late endosomes where it binds P14/MP1/MEK1 complex allowing the ERK cascade.
Upon EGF stimulation EGFR in complex with Grb2 is endocytosed and transported to late endosomes with Grb2-binding proteins such as Sos resulting in the activation of KRas on late endosomes.
PMID:17496910 PMID:19289794
su_mpk1_mpk1_re35( Survival ):
RasGTP interacts with IMP cleaving it from KSR1. In this way KSR1 can play its role of scaffolding protein for ERK cascade.
Ras activation causes the cleavage of 14-3-3 from KSR1 (not modelled) exposing the membrane-targeting C1 domain as well as the docking site for ERK1/2.
PMID:14724641 PMID:17496910
su_mpk1_mpk1_re67( Survival ):
Calcium activates the Ras GAP CAPRI (RASA4) that translocates to the PM and downregulates any Ras that is activated on this compartment by the exchange factor SOS.
PMID:16488589
su_mpk1_mpk1_re102( Survival ):
When Ras assumes an active conformation through binding of GTP a subpopulation of the Raf-1 (C-Raf) protein molecules in cells translocates from the cytosol to the plasma membrane via interaction with P21ras (not modelled).
su_mpk1_mpk1_re137( Survival ):
MEKK1 can interact with Ras in a GTP-dependent manner. The GTP-dependent coupling of MEKK1 to Ras indicates that MEKK1 may be an effector for those agonists that recruit JNK through Ras-dependent mechanisms.
PMID:11274345
su_mpk1_mpk1_re140:( Survival ) Activation of MEKK2 and MEKK3 is assumed to follow the same mechanisms of MEKK1 activation

Modifications:
Participates in complexes:
In compartment: Plasma Membrane

GRB2:RAS*|pho:RTK*:SOS*@Plasma Membrane

Participates in reactions:
As Reactant or Product:

As Catalyser:

IMP*:KSR1:MEK*@Cytoplasm → IMP*@Cytoplasm + KSR1:MEK*@Cytoplasm