Identifiers
NAME:IMP*:KSR1:MEK*
References
su_mpk1_mpk1_re35( Survival ):
RasGTP interacts with IMP cleaving it from KSR1. In this way KSR1 can play its role of scaffolding protein for ERK cascade.
Ras activation causes the cleavage of 14-3-3 from KSR1 (not modelled) exposing the membrane-targeting C1 domain as well as the docking site for ERK1/2.
PMID:14724641 PMID:17496910