Reaction state_transition su_mpk1_mpk1_re186 map

MEK*@Cytoplasm map → MEK*|​pho|​pho@Cytoplasm map

Reaction regulators:
Catalysis
  1. GRB2:​MAP3K10_11*|​pho:​RAC1|​pho:​RTK*:​SOS*@Cytoplasm map
  2. GRB2:​MAP3K2_3*|​pho:​RAS*|​pho:​RTK*:​SOS*@Cytoplasm map
  3. MAP3K2_3*|​pho:​TNFRSF1B:​TRAF2@Cytoplasm map
  4. MAP3K2_3*|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
  5. RAF1|​pho@Cytoplasm map


References
MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner.
MEKK2 and MEKK3 can activate JNK P38 and ERK pathways
MLK3 has the potential to positively regulate the ERK pathway by directly phosphorylating and activating MEK.
PMID:11274345 PMID:12738796