Protein IGF1R map

Identifiers
HGNC:5465
insulin like growth factor 1 receptor
HUGO:IGF1R hgnc_id:HGNC:5465 HGNC:5465 ENTREZ:3480 UNIPROT:P08069
HUGO:IGF1R HGNC:5465 ENTREZ:3480 UNIPROT:P08069
HUGO:IGF1R

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:17145802
GASCADE:IGF1R
PMID:24103846 ; PMID:24782617
IGFR pathway is imporatnd for fibroblast activation.
IGF-1 stimulated Col1a1 and Col3a1 expression on stiff substrate. In contrast, IGF-1 treatment on soft substrate resulted in upregulation of ??SMA gene and protein expression, as well as Col1a1 and Col3a1 transcripts. In conclusion, IGF-1 stimulates differentiation of fibroblasts into a myofibroblast phenotype in a soft matrix environment and has a modest effect on ??SMA stress fiber organization in mouse lung fibroblasts.
IGF-1-induced collagen I expression was mediated by extracellular signal-regulated kinase 1/2 (ERK1/2)-dependent mechanism.
IGF-1 significantly increased levels of phospho-IGF-1R and ERK1/2 in a time-dependent manner in both MIFs and CCD-18Co cells.
PMID:12175651; PMID:10086337
Upon IGF-IR autophosphorylation the protein Shc is recruited to the receptor and becomes phosphorylated on tyrosine residues.36 Activated Shc then binds the adaptor Grb2 in an IRS-1-independent manner, leading to activation of the Ras-ERK pathway.36 This pathway of IGF-IR signaling has been most closely associated with cell differentiation and migration, but in some cases also can regulate the machinery of apoptosis, for example, in detachment-induced death, or anoikis, in fibroblasts.
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011

Modifications:
In compartment: Cytosol
  1. IGF1R@Cytosol map
  2. IGF1R|​pho@Cytosol map
In compartment: Membrane
  1. IGF1R@Membrane map
  2. IGF1R|​pho@Membrane map
Participates in complexes:
In compartment: Cytosol
  1. IGF1/2*:​IGF1R@Cytosol map
  2. IGF family*:​IGF1R|​hm2@Cytosol map
  3. IGF family*:​IGF1R|​Y_pho|​hm2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IGF1R@Cytosol map + IGF1/2*@Extracellular Matrix map → map IGF1/2*:​IGF1R@Cytosol map
  2. IGF1/2*:​IGF1R@Cytosol map → map Lymphangiogenesis@Cytosol map
  3. IGF1R@Cytosol map → map IGF1R|​pho@Cytosol map
  4. IGF1R@Cytosol map + IGF family*@Extracellular space map → map IGF family*:​IGF1R|​hm2@Cytosol map
  5. RTK*@Cytosol map → map IGF1R@Cytosol map
  6. IGF family*:​IGF1R|​hm2@Cytosol map → map IGF family*:​IGF1R|​Y_pho|​hm2@Cytosol map
  7. IGF family*:​IGF1R|​Y_pho|​hm2@Cytosol map → map 14-3-3*@Cytosol map
  8. IGF1R@Membrane map → map IGF1R|​pho@Membrane map
  9. IGF1R|​pho@Membrane map → map MAPK_PATHWAYS@Membrane map
As Catalyser:
  1. SHC1@Cytosol map → map SHC1|​pho@Cytosol map
  2. IRS1@Cytosol map → map IRS1|​pho@Cytosol map
  3. SHC1_p66_p52*@Cytosol map → map SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol map
  4. IRS1@Cytosol map → map IRS1|​Y_pho|​active@Cytosol map
  5. MAP3K5@Cytosol map → map MAP3K5|​pho@Cytosol map
  6. IRS*@Membrane map → map IRS*|​pho@Membrane map