Protein FGFR family* map

Identifiers
Fibroblas growth factors FGF
fibroblast growth factor receptor 1
FLT2 "fms-related tyrosine kinase 2" KAL2
HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362
fibroblast growth factor receptor 2
"bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR
HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802
fibroblast growth factor receptor 3
ACH "achondroplasia thanatophoric dwarfism"
HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607
fibroblast growth factor receptor 4
HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455
fms-related tyrosine kinase 1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910

FGFR family*@Cytosol

References
em_re1454( EMT Senescence  map ):
PMID??:10402472
We conclude that a pool of surface E-cadherin is constantly trafficked through an endocytic, recycling pathway and that this may provide a mechanism for regulating the availability of E-cadherin for junction formation in development, tissue remodeling, and tumorigenesis.
PMID:22674073
Clathrin-mediated endocytosis appears to be responsible for two types of growth factor-induced cadherin internalization, FGF-mediated internalization of E-cadherin () and VEGF-mediated internalization of VE-cadherin.

Modifications:
In compartment: Cytosol
  1. FGFR family*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. FGFR family*:​FRS2|​pho@Cytosol map
  2. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. RTK*@Cytosol map → map FGFR family*@Cytosol map
  2. FGFR family*@Cytosol map → map FGFR1@Cytosol map
  3. FGFR family*@Cytosol map → map FGFR2@Cytosol map
  4. FGFR family*@Cytosol map → map FGFR3@Cytosol map
  5. FGFR family*@Cytosol map → map FGFR4@Cytosol map
  6. FGFR family*@Cytosol map + FGF family*@Extracellular space map + Heparin@Extracellular space map → map FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map
  7. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR2|​hm2|​active@Cytosol map
  8. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR1|​hm2|​active@Cytosol map
  9. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR3|​hm2|​active@Cytosol map
  10. FGF family*|​hm2:​FGFR family*:​Heparin|​hm2@Cytosol map → map FGFR4|​hm2|​active@Cytosol map
  11. FRS2|​pho|​active@Cytosol map + FGFR2|​hm2|​active@Cytosol map + GRB2@Cytosol map + SOS*@Cytosol map → map FGFR family*:​FRS2|​pho@Cytosol map
As Catalyser:
  1. Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytosol map → map E-Cadherin*@Clathrin coated vesicle map