Protein EGFR family* map

Identifiers
HUGO:EGFR HUGO:ERBB2 HUGO:ERBB3 HUGO:ERBB4
Receptor tyrosine kinase
epidermal growth factor receptor
"epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB
HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian)
NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)"
HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
LCCS2 "lethal congenital contracture syndrome 2"
HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
"v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4"
HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910
PMID:24970086
Knockdown of NM23-H1 and -H2 (fig. S1, A to E) reduced clathrin-dependent endocytosis of the transferrin (Tf) and epidermal growth factor (EGF) receptors

EGFR family*@Cytosol

References
mo_re217:( motility  map ) PMID:23867504

EGFR family*@Clathrin coated vesicle

References
em_re1494( EMT Senescence  map ):
PMID:24970086
Knockdown of NM23-H1 and -H2 (fig. S1, A to E) reduced clathrin-dependent endocytosis of the transferrin (Tf) and epidermal growth factor (EGF) receptors

Modifications:
In compartment: Clathrin coated vesicle
  1. EGFR family*@Clathrin coated vesicle map
In compartment: Cytosol
  1. EGFR family*@Cytosol map
  2. EGFR family*|​hm2@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. EGF family*:​EGFR family*@Cytosol map
  2. EGF family*:​EGFR family*|​pho@Cytosol map
  3. EGFR family*|​pho|​hm2:​SHC1_p66_p52*|​Y_pho|​S_pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol map + em_s2285 + SOS*@Cytosol map + GRB2@Cytosol map → map EGFR family*|​pho|​hm2:​SHC1_p66_p52*|​Y_pho|​S_pho@Cytosol map
  2. EGFR family*@Cytosol map → map EGFR@Cytosol map
  3. EGFR family*|​hm2@Cytosol map + EGF family*@Extracellular space map → map em_s2349
  4. EGFR family*@Cytosol map → map HER2*@Cytosol map
  5. EGFR family*@Cytosol map → map HER3*@Cytosol map
  6. EGFR family*@Cytosol map → map HER4*@Cytosol map
  7. RTK*@Cytosol map → map EGFR family*@Cytosol map
  8. EGFR family*@Cytosol map → map EGFR family*@Clathrin coated vesicle map
  9. EGFR family*@Cytosol map + EGF family*@default map → map EGF family*:​EGFR family*@Cytosol map
  10. EGF family*:​EGFR family*@Cytosol map → map EGF family*:​EGFR family*|​pho@Cytosol map
  11. EGF family*:​EGFR family*|​pho@Cytosol map → map F-actin???rich membrane protrusions@Cytosol map
  12. EGF family*:​EGFR family*|​pho@Cytosol map → map Actin fibers disassembly@Nucleus map
  13. EGF family*:​EGFR family*|​pho@Cytosol map → map MAPK pathway@default map
  14. EGF family*:​EGFR family*|​pho@Cytosol map → map PI3K AKT MTOR pathway@default map
  15. EGF family*:​EGFR family*|​pho@Cytosol map → map STAT pathway@default map
As Catalyser:
  1. em_emtc_emtc_s3418 → map em_emtc_emtc_s3009