Protein FGF2 map

Identifiers
fibroblast growth factor 2
HUGO:FGF2 hgnc_id:HGNC:3676 HGNC:3676 ENTREZ:2247 UNIPROT:P09038
fibroblast growth factor 2 (basic)
FGFB
HUGO:FGF2 HGNC:3676 ENTREZ:2247 UNIPROT:P09038
HUGO:FGF2
HUGO:FGF2 HGNC:3676 ENTREZ:2247 UNIPROT:P09038 GENECARDS:FGF2 REACTOME:54764 KEGG:2247 ATLASONC:FGF2ID511ch4q27 WIKI:FGF2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_PRODUCTION  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 Innate Immunity  map  / TUMOR_GROWTH  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_NON_CANONICAL  map

References
CASCADE:PGDF
CASCADE:FGF
CASCADE:TGFB
PMID:23123598
paracrine PDGF stimulation of CAFs induces production of the prototypical pro-angiogenic inducer fibroblast growth factor (FGF)-2 in both cervical carcinomas and melanoma [11] and [85].
PMID:18232728
FGF-2 Functionally Contributes to the Angiogenic Phenotype
. FGF-2 and FGF-7 are expressed by CAFs and Repressed by Specific Inhibition of PDGF Receptor Signaling
PMID:21098712; PMID:22652804; PMID:25374926
TGFB induces FGF2 expression and secretion in fibroblasts via SMAD3 and MAPK pathways
PMID:9242465; PMID:19631971
IL1B, FGF2, FGF1, FGF4, PDGF induce HGF expression and production in fibroblasts
 MACROPHAGE  map
 MDSC  map
 MAST_CELL  map
PMID:18776941
Myeloid-derived suppressor cells and macrophages isolated from mouse tumors displayed activated Stat3 and induced angiogenesis in an in vitro tube formation assay via Stat3 induction of angiogenic factors, including VEGF and bFGF.
PMID:18633355
TAM express many pro-angiogenic and angiogenesis-modulating factors in vitro, such as VEGF, basic fibroblast growth factor (bFGF, also known as FGF2), tumour necrosis factor (TNF), interleukin 1 (IL1), chemokine (C-X-C motif) ligand 8 (CXCL8; also known as IL8), cyclooxygenase 2 (COX2, also known as PTGS2), plasminogen activator, urokinase (uPA, also known as PLAU), platelet derived growth factor beta.
PMID:19508171
FGF drives tumor growth
PMID:11874475
Mast cells express end secrete FGF2

Modifications:
In compartment: Cytosol
  1. FGF2@Cytosol map
In compartment: Extracellular space
  1. FGF2@Extracellular space map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. FGF2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: default
  1. FGF2@default map
Participates in complexes:
In compartment: Cytoplasm
  1. FGF2:​RTK*@Cytoplasm map
Participates in reactions:
As Reactant or Product:
  1. FGF2@Cytosol map → map GROWTH_FACTORS_PRODUCTION@default map
  2. FGF2@Cytosol map → map Angiogenesis@default map
  3. rFGF2@Cytosol map → map FGF2@Cytosol map
  4. FGF2@Cytosol map → map FGF2@default map
  5. FGFR1-ligands*@Extracellular space map → map FGF2@Extracellular space map
  6. FGFR3-ligands*@Extracellular space map → map FGF2@Extracellular space map
  7. FGFR4-ligands*@Extracellular space map → map FGF2@Extracellular space map
  8. FGF2@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
  9. FGF2@INNATE_IMMUNE_CELL_Cytosol map → map TUMOR_GROWTH@TUMOR_CELL_AS_EFFECTOR map
  10. rFGF2@INNATE_IMMUNE_CELL_Cytosol map → map FGF2@INNATE_IMMUNE_CELL_Cytosol map
  11. FGF2@Extracellular space map + RTK*@Cytoplasm map → map FGF2:​RTK*@Cytoplasm map
  12. FGF2:​RTK*@Cytoplasm map → map ERK*@Cytoplasm map
As Catalyser:
  1. gHGF@Cytosol map → map rHGF@Cytosol map
  2. FGFR1@Cytosol map → map FGFR1@Cytosol map
  3. gPLAU@Cytosol map → map rPLAU@Cytosol map
  4. Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*:​p120*@Cytoplasm map → map Cytoskeleton:​E-Cadherin*:​_alpha_-Catenin*:​_beta_-Catenin*|​Y142_pho:​p120*@Cytoplasm map