Identifiers
EPH receptor A1
"EphA1", EPHT, EPHT1
HUGO:EPHA1 HGNC:3385 ENTREZ:2041 UNIPROT:P21709
EPH receptor A2
"EphA2"
HUGO:EPHA2 HGNC:3386 ENTREZ:1969 UNIPROT:P29317
EPH receptor B1
"EphB1"
HUGO:EPHB1 HGNC:3392 ENTREZ:2047 UNIPROT:P54762
EPH receptor B2
"EphB2"
HUGO:EPHB2 HGNC:3393 ENTREZ:2048 UNIPROT:P29323
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
References
PMID:20179713
There are 9 EPHA receptors which bind to 5 Ephrin-A ligands and 5 EPHB receptors which bind to 3 transmembrane Ephrin-B ligands.
E-cadherin promotes EPHA2??? ephrin-A1 localization at epithelial cell junctions
EPHA2 is upregulated in many cancers and its expression has been linked to increased malignancy and a poor clinical prognosis.
EPHA2 seems to be preferentially expressed in malignant breast and prostate cancers with a basal phenotype.
EPHA1 is downregulated in advanced human skin and colorectal cancers, EphB receptors are downregulated in advanced colorectal cancer and ephrin-A5 is downregulated in glioblastomas
TNF-alpha, VEGFA and HIF2A upregulate ephrin-A1 in cultured endothelial cells.
Endothelial ephrin-B2 is upregulated by VEGF through the Notch pathway.
PMID:19074825
Eph receptors comprise the largest family of tyrosine kinase receptors, with 16 known members across many species, 14 of which are found in mammals.
Ephs are divided into two distinct A and B classes based on sequence homology of the extracellular domain
→ EPHA2@Cytosol
→ EPHB2@Cytosol
→ EPH family*@Cytosol