Protein PDGFR family* map

Identifiers
platelet-derived growth factor receptor alpha polypeptide
HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234
platelet-derived growth factor receptor beta polypeptide
HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated.
PMID:17496910

Modifications:
In compartment: Cytosol
  1. PDGFR family*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. PDGFR family*@Cytosol map → map PDGFRA@Cytosol map
  2. PDGFR family*@Cytosol map → map PDGFRB@Cytosol map
  3. PDGF family*|​hm2@Extracellular space map + PDGFR family*@Cytosol map → map PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map
  4. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map → map PDGFRB|​hm2|​active@Cytosol map
  5. PDGF family*|​hm2:​PDGFR family*|​hm2@Cytosol map → map PDGFRA|​hm2|​active@Cytosol map
  6. rPDGFR family*@Nucleus map → map PDGFR family*@Cytosol map
  7. RTK*@Cytosol map → map PDGFR family*@Cytosol map
As Catalyser:
  1. SHC1_p66_p52*@Cytosol map → map SHC1_p66_p52*|​Y_pho|​S_pho|​active@Cytosol map
  2. STAT5*@Cytosol map → map STAT5*|​pho|​active@Cytosol map