Complex AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*
Complex composition:
- PRR*
- FZD*
- DVL*
- G_alpha_o*
- AXIN*
- GSK3*
- CK1_alpha_*
- G_beta_*
- G_gamma_*
- LRP5_6*
- CK1_gamma_*
- _beta_-Arrestin2*
- AMER1*
- WNT*
AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*|pho|pho|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
Identifiers
NAME:AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
References
PMID:52226983 PMID:21606194 PMID:20460648
s_wca1_re43( Survival
):
PMID:21606194 PMID:21285348
DVL is again phosphorylated to form PS-DVL. This isoform of DVL leads to depolimerisation of DVL and even distribution in the cell. Which CK1 isoform catalyses this reaction is unknown
Modifications:
Participates in complexes:
In compartment: Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*|pho|pho|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
Participates in reactions:
As Reactant or Product:- AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*|S268_pho|S269_pho@Endosome
→
CK1_epsilon_*:p120*|S268_pho|S269_pho@Endosome
+ E-Cadherin*|pho@Endosome
+ AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*|pho|pho|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
- AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*|pho|pho|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
→
AMER1*:CK1_gamma_*:DVL*|pho|pho|pho|pho:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
+ AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Endosome
As Catalyser: