Reaction state_transition su_wca1_s_wca1_re37 map

AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map

Reaction regulators:
Catalysis
  1. AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm map


Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:20229235 PMID:18077588 PMID:21304492 PMID:21498506
Phosphorylation of the repeat PPSP A allows recruitment of additional GSK/AXIN which phosphorylates LRP5/6 on other PPSP repeats resulting of sequestering of GSK3 and AXIN away from the destruction complex
AMER1 recruits axin and GSk3