Reaction state_transition su_wca1_s_wca1_re33
AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
+ AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Cytoplasm
→ AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
Reaction regulators:
- Catalysis
- G_beta_*:G_gamma_*@Cytoplasm
- AMER1*:PtdIns(4,5)-P2@Cytoplasm
- AMER1*:CK1_gamma_*:PtdIns(4,5)-P2@Cytoplasm
- Inhibition
- DAB2@Cytoplasm
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
References
PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506
AMER1 recruits axin