Complex E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*
Complex composition:
- LRP5_6*
- FZD*
- WNT*
- E-Cadherin*
- G_alpha_o*
- G_beta_*
- G_gamma_*
- GTP
E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
Identifiers
NAME:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
References
s_wca2_re25( Survival
):
Kremen interacts w/ RSPO1 thereby releasing LRP5/6 which can is used for canonical wnt signalling
PMID:12050670
s_wca2_re21( Survival
):
DKK1 can disrupt binding of Fz/LRP6/WNT complex
PMID:11448771
Modifications:
Participates in complexes:
In compartment: Cytoplasm
- E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
Participates in reactions:
As Reactant or Product:- E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
→
LRP5_6*@Cytoplasm
+ E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:WNT*@Cytoplasm
- LRP5_6*@Cytoplasm
→
E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
- E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
→
WNT canonical pathway@Cytoplasm
As Catalyser: