Protein LRP5_6* map

Identifiers
low density lipoprotein receptor-related protein 5
HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197
low density lipoprotein receptor-related protein 6
HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581
HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:075581
HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5
HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:17143292
PMID:16443747
WNT3a requires LRP6 to activate wnt PMID:22433869
PMID:19072724

LRP5_6*@Cytoplasm

References
su_wca1_s_wca2_re21( Survival  map ):
DKK1 can disrupt binding of Fz/LRP6/WNT complex
PMID:11448771
su_wnc1_s_wnc2_re1( Survival  map ):
Wnt5 can binds to LRP5/6 and in this way, physiologically inhibits non-canonical pathway. In Xenopus and mice.
PMID:19056682
su_wca1_s_wca1_re77( Survival  map ):
PMID:22100263
5T4 forms complex with LRP6 resulting in inhibition of the canonical wnt
su_wca1_s_wca2_re20( Survival  map ):
PMID:11433302
PMID:12050670

LRP5_6*@Cytoplasm

References
s_wca2_re21( Survival  map ):
DKK1 can disrupt binding of Fz/LRP6/WNT complex
PMID:11448771
s_wca1_re77( Survival  map ):
PMID:22100263
5T4 forms complex with LRP6 resulting in inhibition of the canonical wnt
s_wca2_re20( Survival  map ):
PMID:11433302
PMID:12050670
s_wnc2_re1( Survival  map ):
Wnt5 can binds to LRP5/6 and in this way, physiologically inhibits non-canonical pathway. In Xenopus and mice.
PMID:19056682

LRP5_6*@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re24:( Survival  map ) PMID:17804805
s_wca2_re25( Survival  map ):
Kremen interacts w/ RSPO1 thereby releasing LRP5/6 which can is used for canonical wnt signalling
PMID:12050670
s_wca2_re70:( Survival  map ) PMID:23022962

Modifications:
In compartment: Cytoplasm
  1. LRP5_6*@Cytoplasm map
  2. LRP5_6*@Cytoplasm map
  3. LRP5_6*@Cytoplasm map
In compartment: Cytosol
  1. LRP5_6*@Cytosol map
Participates in complexes:
In compartment: Cytoplasm
  1. 5T4*:​LRP5_6*@Cytoplasm map
  2. LRP5_6*:​WNT*@Cytoplasm map
  3. CRIPTO-1*:​LRP5_6*@Cytoplasm map
  4. DKK1:​KRM*:​LRP5_6*@Cytoplasm map
  5. DVL*|​pho|​pho|​pho:​LRP5_6*:​WNT*@Cytoplasm map
  6. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map
  7. CRIPTO-1*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map
  8. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*:​p120*@Cytoplasm map
  9. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LGR5:​LRP5_6*:​RSPO1-4*:​WNT*:​p120*@Cytoplasm map
In compartment: Cytosol
  1. FZD*:​LRP5_6*:​WNT*@Cytosol map
  2. DVL1:​FZD*:​LRP5_6*:​WNT*@Cytosol map
In compartment: Endosome
  1. DKK1:​KRM*:​LRP5_6*@Endosome map
  2. AMER1*:​CK1_gamma_*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  4. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  5. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  6. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  8. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  9. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  10. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
In compartment: Vaceolae
  1. CK1_epsilon_*:​E-Cadherin*:​LRP5_6*:​p120*@Vaceolae map
  2. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map
  3. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  4. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
Participates in reactions:
As Reactant or Product:
  1. FZD*@Cytosol map + WNT*@Extracellular space map + LRP5_6*@Cytosol map → map FZD*:​LRP5_6*:​WNT*@Cytosol map
  2. DVL1@Cytosol map + FZD*:​LRP5_6*:​WNT*@Cytosol map → map DVL1:​FZD*:​LRP5_6*:​WNT*@Cytosol map
  3. WNT*@default map + CK1_epsilon_*:​E-Cadherin*:​LRP5_6*:​p120*@Vaceolae map + FZD*:​GDP:​G_alpha_o*:​G_beta_*:​G_gamma_*@Cytoplasm map + GTP@Vaceolae map + PRR*@Cytoplasm map → map CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + GDP@Vaceolae map
  4. DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm map → map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + GTP:​G_alpha_o*@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map
  5. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map → map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  6. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  8. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  9. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  10. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  11. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  12. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map → map CK1_epsilon_*:​p120*|​S268_pho|​S269_pho@Endosome map + E-Cadherin*|​pho@Endosome map + AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  13. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map → map AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map
  14. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map → map Recycling @Cytoplasm map
  15. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map → map Degradation@Cytoplasm map
  16. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map → map DVL*|​pho|​pho|​pho|​pho@Endosome map + AMER1*:​CK1_gamma_*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  17. 5T4*@Cytoplasm map + LRP5_6*@Cytoplasm map → map 5T4*:​LRP5_6*@Cytoplasm map
  18. 5T4*:​LRP5_6*@Cytoplasm map → map WNT non canonical pathway@Extracellular space map
  19. DKK1@default map + LRP5_6*@Cytoplasm map + KRM*@Cytoplasm map → map DKK1:​KRM*:​LRP5_6*@Cytoplasm map
  20. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map → map LRP5_6*@Cytoplasm map + E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm map
  21. DKK1:​KRM*:​LRP5_6*@Cytoplasm map → map DKK1:​KRM*:​LRP5_6*@Endosome map
  22. DKK1:​KRM*:​LRP5_6*@Cytoplasm map + RSPO1@default map → map KRM*:​RSPO1@Cytoplasm map + DKK1@default map + LRP5_6*@Cytoplasm map
  23. LRP5_6*@Cytoplasm map → map E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map
  24. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map → map WNT canonical pathway@Cytoplasm map
  25. LRP5_6*@Cytoplasm map + CRIPTO-1*@Cytoplasm map → map CRIPTO-1*:​LRP5_6*@Cytoplasm map
  26. CRIPTO-1*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map → map WNT canonical pathway@Cytoplasm map
  27. E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm map + CRIPTO-1*:​LRP5_6*@Cytoplasm map → map CRIPTO-1*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*@Cytoplasm map
  28. LGR5:​RSPO1-4*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LRP5_6*:​WNT*:​p120*@Cytoplasm map → map CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LGR5:​LRP5_6*:​RSPO1-4*:​WNT*:​p120*@Cytoplasm map
  29. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​LGR5:​LRP5_6*:​RSPO1-4*:​WNT*:​p120*@Cytoplasm map → map WNT canonical pathway@Cytoplasm map
  30. WNT*@default map + LRP5_6*@Cytoplasm map → map LRP5_6*:​WNT*@Cytoplasm map
  31. LRP5_6*:​WNT*@Cytoplasm map + DVL*@Cytoplasm map → map DVL*|​pho|​pho|​pho:​LRP5_6*:​WNT*@Cytoplasm map
As Catalyser:
  1. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map → map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  2. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  3. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  4. DVL*@Cytoplasm map + CUL3:​KLHL*:​RBX1@Cytoplasm map → map CUL3:​DVL*:​KLHL*:​RBX1@Cytoplasm map
  5. JBN*:​_beta_-Catenin*@Cytoplasm map → map JBN*:​_beta_-Catenin*@Cilium map
  6. JBN*:​_beta_-Catenin*@Cilium map → map su_wca1_s_wca1_s764
  7. ATP6V0C_D*@Vaceolae map → map ATP6V0C_D*@Vaceolae map
  8. DKK1:​KRM*:​LRP5_6*@Cytoplasm map → map DKK1:​KRM*:​LRP5_6*@Endosome map