Reaction heterodimer_association su_wca1_s_wca1_re28 map

DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm map → AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + GTP:​G_alpha_o*@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map

Reaction regulators:
Trigger
  1. H+@Vaceolae map


Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map

References
PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133
Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor
An acidic environment is required for phosphorylation of DVL and LRP5/6