Identifiers
NAME:AMER1*:CK1_gamma_*:PtdIns
References
s_wca1_re60:( Survival ) PMID:21304492
s_wca1_re28( Survival ):
PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133
Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor
An acidic environment is required for phosphorylation of DVL and LRP5/6
s_wca1_re33( Survival ):
PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506
AMER1 recruits axin
s_wca1_re37( Survival ):
PMID:20229235 PMID:18077588 PMID:21304492 PMID:21498506
Phosphorylation of the repeat PPSP A allows recruitment of additional GSK/AXIN which phosphorylates LRP5/6 on other PPSP repeats resulting of sequestering of GSK3 and AXIN away from the destruction complex
AMER1 recruits axin and GSk3
+ CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*@Vaceolae + AMER1*:CK1_gamma_*:PtdIns(4,5)-P2@Cytoplasm → AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae + GTP:G_alpha_o*@Cytoplasm + G_beta_*:G_gamma_*@Cytoplasm
+ AMER1*:PtdIns(4,5)-P2@Cytoplasm → AMER1*:CK1_gamma_*:PtdIns(4,5)-P2@Cytoplasm
+ AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Cytoplasm → AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
+ AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Cytoplasm → AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome