Identifiers
wingless-type MMTV integration site family member 1
HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628
wingless-type MMTV integration site family member 2
HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544
wingless-type MMTV integration site family member 2B
HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097
wingless-type MMTV integration site family member 3
HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703
wingless-type MMTV integration site family member 3A
HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704
wingless-type MMTV integration site family member 4
HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705
wingless-type MMTV integration site family member 5A
HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221
wingless-type MMTV integration site family member 5B
HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7
wingless-type MMTV integration site family member 6
HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9
wingless-type MMTV integration site family member 7A
HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755
wingless-type MMTV integration site family member 7B
HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706
wingless-type MMTV integration site family member 8A
HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5
wingless-type MMTV integration site family member 8B
HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098
wingless-type MMTV integration site family member 9A
HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904
wingless-type MMTV integration site family member 9B
HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905
wingless-type MMTV integration site family member 10A
HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5
wingless-type MMTV integration site family member 10B
HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744
wingless-type MMTV integration site family member 11
HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014
wingless-type MMTV integration site family member 16
HUGO:WNT16 HGNC/16267 ENTREZ:51384 UNIPROT:Q9UBV4
wingless-type MMTV integration site family member 5
WNT5A antisense RNA 1
HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008
HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4
HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1
HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2
HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B
HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3
HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A
HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4
HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A
HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B
HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6
HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A
HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B
HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A
HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B
HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A
HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B
HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A
HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B
HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11
HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16
HGNC/16267
HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
Survival / WNT_NON_CANONICAL
References
Class I: WNT-1,3a,7,8a,8b activates canonical
PMID:14747478
PMID:15265686
PMID:8655584
PMID:22017973
PMID:17127310
Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478
References
ClasII: Wnt4,-5a,-5b, and -11
Apperently wnt-3a is also able to induce the PCP MODULE
PMID:18187455
su_wnc1_s_wnc1_re49( Survival ):
PMID:20628572
PMID:12839624
su_wnc1_s_wnc1_re62( Survival ):
Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex
PMID:18606138
Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE.
PMID:16604063
PMID:21397842
Vangl-2 forms complex upon binding with Wnt-5
PMID:21316585
ROR2 is associated with Wnt, Fzl and CK1_epsilon
PMID:20215527
PPR binds to Fzl in both canonical and non-canonical MODULE
PMID:20093472
PMID:21380625
PMID:20579883
su_wnc1_s_wnc2_re1( Survival ):
Wnt5 can binds to LRP5/6 and in this way, physiologically inhibits non-canonical pathway. In Xenopus and mice.
PMID:19056682
su_wca1_s_wca1_re25:( Survival ) PMID:21606194 PMID:19705439
su_wca1_s_wca2_re30( Survival ):
Shown in Xenopus embryos that dimerisation of XFZ3 correlates with activation. This phenomenon is described once in:
PMID:12734397
References
Wnt5 (non-canonical)
References
s_wca1_re25:( Survival ) PMID:21606194 PMID:19705439
s_wca2_re30( Survival ):
Shown in Xenopus embryos that dimerisation of XFZ3 correlates with activation. This phenomenon is described once in:
PMID:12734397
s_wnc1_re49( Survival ):
PMID:20628572
PMID:12839624
s_wnc1_re62( Survival ):
Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex
PMID:18606138
Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE.
PMID:16604063
PMID:21397842
Vangl-2 forms complex upon binding with Wnt-5
PMID:21316585
ROR2 is associated with Wnt, Fzl and CK1_epsilon
PMID:20215527
PPR binds to Fzl in both canonical and non-canonical MODULE
PMID:20093472
PMID:21380625
PMID:20579883
s_wnc2_re1( Survival ):
Wnt5 can binds to LRP5/6 and in this way, physiologically inhibits non-canonical pathway. In Xenopus and mice.
PMID:19056682
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
+ WNT*@Extracellular space + LRP5_6*@Cytosol → FZD*:LRP5_6*:WNT*@Cytosol
+ FZD*:LRP5_6*:WNT*@Cytosol → DVL1:FZD*:LRP5_6*:WNT*@Cytosol
+ CK1_epsilon_*:E-Cadherin*:LRP5_6*:p120*@Vaceolae + FZD*:GDP:G_alpha_o*:G_beta_*:G_gamma_*@Cytoplasm + GTP@Vaceolae + PRR*@Cytoplasm → CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*@Vaceolae + GDP@Vaceolae
+ CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*@Vaceolae + AMER1*:CK1_gamma_*:PtdIns(4,5)-P2@Cytoplasm → AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae + GTP:G_alpha_o*@Cytoplasm + G_beta_*:G_gamma_*@Cytoplasm
→ AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
+ AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Cytoplasm → AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→ AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
+ AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Cytoplasm → AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→ AMER1*:APC:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→ AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→ AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*|S268_pho|S269_pho@Endosome
→ CK1_epsilon_*:p120*|S268_pho|S269_pho@Endosome + E-Cadherin*|pho@Endosome + AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*|pho|pho|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
→ AMER1*:CK1_gamma_*:DVL*|pho|pho|pho|pho:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome + AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2*@Endosome
→ Recycling @Cytoplasm
→ Degradation@Cytoplasm
→ DVL*|pho|pho|pho|pho@Endosome + AMER1*:CK1_gamma_*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*@Endosome
→ LRP5_6*@Cytoplasm + E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:WNT*@Cytoplasm
→ E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
→ WNT canonical pathway@Cytoplasm
+ XFZ3@Cytoplasm → WNT*:XFZ3@Cytoplasm
→ WNT canonical pathway@Cytoplasm
→ WNT canonical pathway@Cytoplasm
+ CRIPTO-1*:LRP5_6*@Cytoplasm → CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
+ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome → CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RAC1:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
+ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome → APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:PRR*:RACK1*:ROR2|S864_pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
+ RSPO3@Cytoplasm → CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm + SMURF1@Cytoplasm + PRICKLE1|pho|ubi@Cytoplasm
→ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
→ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
→ RAC1@Cytoplasm + CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
+ WGEF*@Cytoplasm + DAAM1@Cytoplasm + RHOA@Cytoplasm → APC2*:CK1_epsilon_*:CTHRC1:DAAM1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:RHOA:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WGEF*:WNT*:_beta_-Arrestin2*@Cytoplasm
→ Angiogenesis@Nucleus
→ APC2*:CK1_epsilon_*:CTHRC1:DAAM1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WGEF*:WNT*:_beta_-Arrestin2*@Cytoplasm + RHOA@Cytoplasm
+ CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:LRP5_6*:WNT*:p120*@Cytoplasm → CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:LGR5:LRP5_6*:RSPO1-4*:WNT*:p120*@Cytoplasm
→ WNT canonical pathway@Cytoplasm
+ FZD*:GDP:G_alpha_*:G_beta_*:G_gamma_*@Cytoplasm + GTP@Cytoplasm → FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:WNT*@Cytoplasm + GDP@Cytoplasm
→ G_beta_*:G_gamma_*@Cytoplasm + GTP:G_alpha_*@Cytoplasm
+ FZD*:GDP:G_alpha_*:G_beta_*:G_gamma_*@Cytoplasm + WNT*@default + GTP@Cytoplasm + CK1_epsilon_*@Cytoplasm + CTHRC1@Cytoplasm + SYN4*@Cytoplasm + PAR6*:PRICKLE1|pho:RACK1*:VANGL*@Cytoplasm + PRR*@Cytoplasm → CK1_epsilon_*:CTHRC1:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*@Cytoplasm + GDP@Cytoplasm
→ GTP:G_alpha_*@Cytoplasm + CK1_epsilon_*:CTHRC1:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*@Cytoplasm + G_beta_*:G_gamma_*@Cytoplasm
+ DVL*|pho|S142_emp|S139_emp:_beta_-Arrestin2*@Cytoplasm → CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
→ WNT canonical pathway@Cytoplasm
→ APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome
→ APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*|pho|pho|pho|pho:WNT*:_beta_-Arrestin2*@Endosome
→ CK1_epsilon_*:CTHRC1:FZD*:PAR6*:PRICKLE1|pho:RACK1*:ROR2|S864_emp|emp|emp:SYN4*:VANGL*|emp|emp|emp|emp:WNT*:_beta_-Arrestin2*@Cytoplasm + DVL*|pho|S142_emp|S139_emp|ubi@Cytoplasm
→ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:RACK1*:ROR2|S864_emp|emp|emp:SYN4*:VANGL*|emp|emp|emp|emp:WNT*:_beta_-Arrestin2*@Cytoplasm
+ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm → CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
→ CK1_epsilon_*:CTHRC1:DVL*|pho|S142_emp|S139_emp:FZD*:PAR6*:PRICKLE1|pho|ubi:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Cytoplasm
+ LRP5_6*@Cytoplasm → LRP5_6*:WNT*@Cytoplasm
+ DVL*@Cytoplasm → DVL*|pho|pho|pho:LRP5_6*:WNT*@Cytoplasm
→ AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae
→ AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome
→ AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*|pho:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho|T1530_pho|S1533_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*|S268_pho|S269_pho@Endosome
+ CUL3:KLHL*:RBX1@Cytoplasm → CUL3:DVL*:KLHL*:RBX1@Cytoplasm
→ JBN*:_beta_-Catenin*@Cilium
→ su_wca1_s_wca1_s764
→ ATP6V0C_D*@Vaceolae
→ ATP6V0C_D*@Endosome
→ ATP6V0C_D*@Endosome
→ APC2*:CK1_epsilon_*:CTHRC1:DVL*|pho|S142_pho|S139_pho:FZD*:GSK3*:PAR6*:RACK1*:ROR2|S864_pho|pho|pho:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*@Endosome