Identifiers
dishevelled dsh homolog 1 (Drosophila)
HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1
dishevelled dsh homolog 2 (Drosophila)
HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2
dishevelled dsh homolog 3 (Drosophila)
HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3
"dishevelled 1 (homologous to Drosophila dsh)"

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 
 Survival   / WNT_NON_CANONICAL 

References
PMID:20006983

References
s_wnc1_re65( Survival  ):
Active PKC phosphorylates Dvl, just not enough to achieve the PS-form.
PMID:12958364
s_wnc1_re95:( Survival  ) PMID:16446366

References
s_wnc1_re15:( Survival  ) PMID:20223821

References
s_wnc1_re65( Survival  ):
Active PKC phosphorylates Dvl, just not enough to achieve the PS-form.
PMID:12958364

References
s_wca3_re167( Survival  ):
Contains a NES
PMID:15720724
s_wca1_re26( Survival  ):
PMID:16707567 PMID:21285348
DVL is primed by CK2 and/or MARK2
s_wca1_re51( Survival  ):
PMID:16547521
In the presence of WNT3a DVL-3 forms complex with KLHL12/CUL3/RBX1-complex
s_wca1_re53:( Survival  ) PMID:15852005
s_wca1_re79:( Survival  ) PMID:11113207 PMID:18931698
s_wca3_re168( Survival  ):
contains NLS import higher when stimulated with wnt3
s_wnc1_re15:( Survival  ) PMID:20223821
s_wnc2_re3( Survival  ):
Binding of Wnt5 and LRP5/6 leads to phosphorylation of Dvl. Most likely the same residues as picture shows same speed of migration on gel compared to Wnt3 stimulation. No phosphorylation of LRP5/6 by Wnt5. This complex formation sequesters away Wnt5 from the non-canonical pathway receptors
PMID:19056682
s_wnc4_re45:( Survival  ) PMID:17588722

References
s_wca1_re26( Survival  ):
PMID:16707567 PMID:21285348
DVL is primed by CK2 and/or MARK2
s_wca1_re29( Survival  ):
PMID:19705439 PMID:17426148
Beta-ARRESTIN binds to phosphorylated DVL

References
s_wca3_re168( Survival  ):
contains NLS import higher when stimulated with wnt3
PMID:15720724
s_wca3_re139:( Survival  ) PMID:19183803
s_wca3_re167( Survival  ):
Contains a NES
s_wca3_re169( Survival  ):
Upon WNT3a stimulation formation complex DVL with c-jun
PMID:18347071
su_wca1_s_wca3_re167( Survival  ):

1. DVL*@Cytoplasm
2. DVL*@Cytoplasm
3. DVL*@Cytoplasm
4. DVL*@Cytoplasm
5. DVL*@Cytoplasm
6. DVL*|​pho|​emp|​emp@Cytoplasm
7. DVL*|​pho|​S142_emp|​S139_emp@Cytoplasm
8. DVL*|​pho|​S142_pho|​S139_pho@Cytoplasm
9. DVL*|​pho|​S142_emp|​S139_emp|​ubi@Cytoplasm

1. DVL*|​pho|​pho|​pho|​pho@Endosome

1. DVL*@Nucleus

1. DVL*:​Iversin*@Cilium

1. DACT1:​DVL*@Cytoplasm
2. DVL*:​IDAX*@Cytoplasm
3. DVL*:​Iversin*@Cytoplasm
4. DVL*|​pho|​S142_emp|​S139_emp:​_beta_-Arrestin2*@Cytoplasm
5. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm
6. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm
7. DVL*|​pho|​pho|​pho:​LRP5_6*:​WNT*@Cytoplasm
8. CUL3:​DVL*:​KLHL*:​RBX1@Cytoplasm
9. DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm
10. APC:​AXIN*:​Actin cytoskeletal*:​DVL*:​HSC70*:​HSP70*:​HTID1_50_48_kDa_isoform*@Cytoplasm
11. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​RACK1*:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​WNT*:​_beta_-Arrestin2*@Cytoplasm
12. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
13. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
14. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
15. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho|​ubi:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
16. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
17. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm

1. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
2. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
3. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
4. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
5. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
6. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
8. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome
9. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
10. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
11. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
12. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
13. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
14. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome
15. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome

1. DVL*:​HIPK1@Nucleus
2. DVL*:​JUN|​pho|​pho@Nucleus
3. BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
4. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus
5. BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
6. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus
7. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus

1. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae
2. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae

1. DVL*@Cytoplasm → DVL*|​pho|​emp|​emp@Cytoplasm
2. DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm → AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae + GTP:​G_alpha_o*@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm
3. DVL*|​pho|​emp|​emp@Cytoplasm + G_beta_*:​G_gamma_*@Cytoplasm + _beta_-Arrestin2*@Cytoplasm → DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm
4. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae → AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae
5. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
6. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
8. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
9. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
10. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome
11. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome → CK1_epsilon_*:​p120*|​S268_pho|​S269_pho@Endosome + E-Cadherin*|​pho@Endosome + AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
12. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome → AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome
13. DVL*@Cytoplasm + CUL3:​KLHL*:​RBX1@Cytoplasm → CUL3:​DVL*:​KLHL*:​RBX1@Cytoplasm
14. DVL*@Cytoplasm + Iversin*@Cytoplasm → DVL*:​Iversin*@Cytoplasm
15. DVL*:​Iversin*@Cytoplasm → DVL*:​Iversin*@Cilium
16. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome → Recycling @Cytoplasm
17. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome → Degradation@Cytoplasm
18. AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome → DVL*|​pho|​pho|​pho|​pho@Endosome + AMER1*:​CK1_gamma_*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
19. IDAX*@Cytoplasm + DVL*@Cytoplasm → DVL*:​IDAX*@Cytoplasm
20. APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus + BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus → APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
21. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus → APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + su_wca1_s_wca3_s405 + CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus + DVL*:​JUN|​pho|​pho@Nucleus
22. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus + BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus → BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus + HDAC1_2*:​TLE*|​ubi@Nucleus
23. HIPK1@Nucleus + DVL*@Nucleus → DVL*:​HIPK1@Nucleus
24. DVL*@Nucleus → DVL*@Cytoplasm
25. DVL*@Cytoplasm → DVL*@Nucleus
26. JUN|​pho|​pho@Nucleus + DVL*@Nucleus → DVL*:​JUN|​pho|​pho@Nucleus
27. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + DVL*:​JUN|​pho|​pho@Nucleus → BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus
28. DVL*:​JUN|​pho|​pho@Nucleus + BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus → BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus
29. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus + BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus → BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace@Nucleus + HDAC1_2*:​TLE*|​ubi@Nucleus
30. RAC1@Cytoplasm + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
31. APC2*:​GSK3*@Cytoplasm + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
32. GTP:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm + DVL*|​pho|​S142_emp|​S139_emp@Cytoplasm → DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm
33. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho|​ubi:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm + RSPO3@Cytoplasm → CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm + SMURF1@Cytoplasm + PRICKLE1|​pho|​ubi@Cytoplasm
34. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm → CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
35. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm → CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
36. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm → DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm
37. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → RAC1@Cytoplasm + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
38. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome + WGEF*@Cytoplasm + DAAM1@Cytoplasm + RHOA@Cytoplasm → APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
39. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm → Angiogenesis@Nucleus
40. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm → APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm + RHOA@Cytoplasm
41. DVL*@Cytoplasm → DVL*|​pho|​S142_emp|​S139_emp@Cytoplasm
42. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm → _beta_-catenin stability@Nucleus
43. DVL*@Cytoplasm → DVL*|​pho|​S142_pho|​S139_pho@Cytoplasm
44. CK1_epsilon_*:​CTHRC1:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm + DVL*|​pho|​S142_emp|​S139_emp:​_beta_-Arrestin2*@Cytoplasm → CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
45. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → WNT canonical pathway@Cytoplasm
46. _beta_-Arrestin2*@Cytoplasm + DVL*|​pho|​S142_pho|​S139_pho@Cytoplasm → DVL*|​pho|​S142_emp|​S139_emp:​_beta_-Arrestin2*@Cytoplasm
47. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
48. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome
49. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​RACK1*:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​WNT*:​_beta_-Arrestin2*@Cytoplasm → CK1_epsilon_*:​CTHRC1:​FZD*:​PAR6*:​PRICKLE1|​pho:​RACK1*:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​WNT*:​_beta_-Arrestin2*@Cytoplasm + DVL*|​pho|​S142_emp|​S139_emp|​ubi@Cytoplasm
50. DVL*|​pho|​S142_emp|​S139_emp|​ubi@Cytoplasm → degraded
51. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm → CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​RACK1*:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​WNT*:​_beta_-Arrestin2*@Cytoplasm
52. SMURF1@Cytoplasm + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm → CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
53. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm → CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho|​ubi:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
54. DACT1@Cytoplasm + DVL*@Cytoplasm → DACT1:​DVL*@Cytoplasm
55. DACT1:​DVL*@Cytoplasm → degraded
56. LRP5_6*:​WNT*@Cytoplasm + DVL*@Cytoplasm → DVL*|​pho|​pho|​pho:​LRP5_6*:​WNT*@Cytoplasm
57. APC@Cytoplasm + HTID1_50_48_kDa_isoform*@Cytoplasm + HSP70*@Cytoplasm + DVL*@Cytoplasm + Actin cytoskeletal*@Cytoplasm + AXIN*@Cytoplasm + HSC70*@Cytoplasm → APC:​AXIN*:​Actin cytoskeletal*:​DVL*:​HSC70*:​HSP70*:​HTID1_50_48_kDa_isoform*@Cytoplasm

1. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae → AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae
2. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
3. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome
4. gGenes under control of _br_CBP-mediated transcription*@Nucleus → rRNA@Nucleus
5. gTCF4@Nucleus → rTCF4@Nucleus
6. gRAD6B*@Nucleus → rRAD6B*@Nucleus
7. gBCL9@Nucleus → rBCL9@Nucleus
8. gMIR372@Nucleus → arMIR372@Nucleus
9. gMIR373@Nucleus → arMIR373@Nucleus
10. gIRS2@Nucleus → rIRS2@Nucleus
11. gCRIPTO-1*@Nucleus → rCRIPTO-1*@Nucleus
12. gMYC@Nucleus → rMYC@Nucleus
13. gGene under control of_br_ P300-mediated transcription*@Nucleus → rRNA@Nucleus
14. ATP6V0C_D*@Cytoplasm → ATP6V0C_D*@Endosome
15. ATP6V0C_D*@Cytoplasm → ATP6V0C_D*@Endosome
16. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome