Identifiers
NAME:CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
References
PMID:20940130 PMID:21606194
s_wca1_re25:( Survival ) PMID:21606194 PMID:19705439
s_wca1_re28( Survival ):
PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133
Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor
An acidic environment is required for phosphorylation of DVL and LRP5/6
s_wca1_re51( Survival ):
PMID:16547521
In the presence of WNT3a DVL-3 forms complex with KLHL12/CUL3/RBX1-complex
s_wca1_re57( Survival ):
PMID:19718039 PMID:21602792
In presence of WNT ligand
s_wca1_re68( Survival ):
PMID:20093472
PRR binds to subunits ATP6V0C and D those are subunits of the V-ATPase.
+ CK1_epsilon_*:E-Cadherin*:LRP5_6*:p120*@Vaceolae + FZD*:GDP:G_alpha_o*:G_beta_*:G_gamma_*@Cytoplasm + GTP@Vaceolae + PRR*@Cytoplasm → CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*@Vaceolae + GDP@Vaceolae
+ CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*@Vaceolae + AMER1*:CK1_gamma_*:PtdIns(4,5)-P2@Cytoplasm → AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120*@Vaceolae + GTP:G_alpha_o*@Cytoplasm + G_beta_*:G_gamma_*@Cytoplasm