Complex G_beta_*:G_gamma_* map
Complex composition:

  1. G_beta_* map
  2. G_gamma_* map

G_beta_*:​G_gamma_*@Cytoplasm

Identifiers
NAME:G_beta_*:G_gamma_*

G_beta_*:​G_gamma_*@Endoplasmic Reticulum

Identifiers
NAME:G_beta_*:G_gamma_*

References
Ca2+/Wnt MODULE
s_wnc1_re29:( Survival  map ) PMID:12747838

G_beta_*:​G_gamma_*@Cytosol

Identifiers
NAME:G_beta_*:G_gamma_*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
Class I: WNT-1,3a,7,8a,8b activates canonical
PMID:14747478
PMID:15265686
PMID:8655584
PMID:22017973
PMID:17127310

G_beta_*:​G_gamma_*@Cytoplasm

Identifiers
NAME:G_beta_*:G_gamma_*

References
Ca2+/Wnt MODULE
su_wnc1_s_wnc1_re50:( Survival  map ) PMID:20628572
su_wnc1_s_wnc1_re64( Survival  map ):
For the Fzl receptor, probably same mechanism as for the canonical MODULE.
CK1 epsilon is activated upon Wnt-5 stimulation, however, the mechanism is unknown.
PMID:17244647
PMID:20215527
su_wca1_s_wca1_re28( Survival  map ):
PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133
Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor
An acidic environment is required for phosphorylation of DVL and LRP5/6
su_wnc1_s_wnc1_re29:( Survival  map ) PMID:12747838
su_wnc1_s_wnc1_re31:( Survival  map ) PMID:21736902
su_wnc1_s_wnc1_re54:( Survival  map ) PMID:10999941
su_wnc1_s_wnc1_re57( Survival  map ):
PLC-beta_2 and 3 are activated by the beta-and gamma subunit of the G-protein class q
PMID:20553968
su_wca1_s_wca1_re29( Survival  map ):
PMID:19705439 PMID:17426148
Beta-ARRESTIN binds to phosphorylated DVL
su_wca1_s_wca1_re33( Survival  map ):
PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506
AMER1 recruits axin

Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. G_beta_*:​G_gamma_*@Cytoplasm map
  2. G_beta_*:​G_gamma_*@Cytoplasm map
In compartment: Cytosol
  1. G_beta_*:​G_gamma_*@Cytosol map
In compartment: Endoplasmic Reticulum
  1. G_beta_*:​G_gamma_*@Endoplasmic Reticulum map
Participates in reactions:
As Reactant or Product:
  1. G_beta_*:​G_gamma_*@Cytosol map + p101*:​p110_beta__gamma_*@Cytosol map → map p101*:​p110_beta__gamma_*@Cytosol map
  2. G_alpha__sub_i_endsub_*:​Ligand@Cytosol map → map PTCH*@Cytosol map + su_shh1_s_shh3_s60 + G_beta_*:​G_gamma_*@Cytosol map + SMO@Cytosol map
  3. GRK*@Cytosol map + G_beta_*:​G_gamma_*@Cytosol map → map su_shh1_s_shh3_s69
  4. DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm map → map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + GTP:​G_alpha_o*@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map
  5. DVL*|​pho|​emp|​emp@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map + _beta_-Arrestin2*@Cytoplasm map → map DVL*|​pho|​emp|​emp:​G_beta_*:​G_gamma_*:​_beta_-Arrestin2*@Cytoplasm map
  6. G_beta_*:​G_gamma_*@Cytoplasm map + IP3R*@Endoplasmic Reticulum map → map G_beta_*:​G_gamma_*@Endoplasmic Reticulum map
  7. G_beta_*:​G_gamma_*@Cytoplasm map + p101*:​p110_beta__gamma_*@Cytoplasm map → map G_beta_*:​G_gamma_*:​p101*:​p110_beta__gamma_*@Cytoplasm map
  8. G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*:​LRP6:​PTH@Cytoplasm map → map GTP:​G_alpha__sub_s_endsub_*@Cytoplasm map + LRP6@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map + PTH@default map
  9. FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​WNT*@Cytoplasm map → map G_beta_*:​G_gamma_*@Cytoplasm map + GTP:​G_alpha_*@Cytoplasm map
  10. GTP:​G_alpha__sub_s_endsub_*@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map → map GDP:​G_alpha__sub_s_endsub_*:​G_beta_*:​G_gamma_*@Cytoplasm map
  11. G_beta_*:​G_gamma_*@Cytoplasm map + PLC-_beta_*@Cytoplasm map → map G_beta_*:​G_gamma_*:​PLC-_beta_*@Cytoplasm map
  12. CK1_epsilon_*:​CTHRC1:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm map → map GTP:​G_alpha_*@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map
  13. GTP:​G_alpha__sub_13q_endsub_*:​G_beta_*:​G_gamma_*:​PAR1_sub_TRUNC_endsub_*:​_beta_-Arrestin*@Cytoplasm map → map PAR1_sub_TRUNC_endsub_*@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map + GTP:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
As Catalyser:
  1. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map → map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  2. Ca2+@Endoplasmic Reticulum map → map Ca2+@Cytoplasm map