Identifiers
cyclin A1
HUGO:CCNA1, HGNC:1577, ENTREZ:8900, UNIPROT:P78396

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair   / S_CC_PHASE 

References
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786

1. CyclinA1*@Nucleus

1. CDK1:​CyclinA1*@Nucleus
2. CyclinA1*:​p107*@Nucleus
3. CIP1_KIP1*:​CyclinA1*@Nucleus
4. CDK1|​Y14/15_pho:​CyclinA1*@Nucleus
5. CDK2|​Y14/15_pho:​CyclinA1*@Nucleus
6. (CDK2|​T160_pho:​CyclinA1*)|​active@Nucleus
7. CDK2|​T160_pho|​Y14/15_pho:​CyclinA1*@Nucleus
8. (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@Nucleus
9. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20|​pho:​CyclinA1*@Nucleus

1. CDK2@Nucleus + CyclinA1*@Nucleus → ce_s3123
2. CIP1_KIP1*@Nucleus + ce_s3123 → CIP1_KIP1*:​CyclinA1*@Nucleus
3. CyclinA1*@Nucleus → degraded
4. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus → APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20|​pho:​CyclinA1*@Nucleus
5. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20|​pho:​CyclinA1*@Nucleus → APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@Nucleus
6. CIP1_KIP1*:​CyclinA1*@Nucleus → ce_s3123 + CIP1_KIP1*@Nucleus
7. ce_s3123 → CDK2@Nucleus + CyclinA1*@Nucleus
8. p107*@Nucleus + ce_s3123 → CyclinA1*:​p107*@Nucleus
9. rCyclinA1*@Nucleus → CyclinA1*@Nucleus
10. ce_s3123 → CDK2|​Y14/15_pho:​CyclinA1*@Nucleus
11. CDK2|​Y14/15_pho:​CyclinA1*@Nucleus → CDK2|​T160_pho|​Y14/15_pho:​CyclinA1*@Nucleus
12. CDK2|​T160_pho|​Y14/15_pho:​CyclinA1*@Nucleus → (CDK2|​T160_pho:​CyclinA1*)|​active@Nucleus
13. CyclinA1*@Nucleus + CDK1@Nucleus → CDK1:​CyclinA1*@Nucleus
14. CDK1:​CyclinA1*@Nucleus → CDK1|​Y14/15_pho:​CyclinA1*@Nucleus
15. CDK1|​Y14/15_pho:​CyclinA1*@Nucleus → (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@Nucleus
16. (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@Nucleus → (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@Nucleus
17. (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@Nucleus → (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@Nucleus

1. S phase@Nucleus → G2 phase@Nucleus
2. M phase@Nucleus → G1 phase@Nucleus
3. TP53BP1@Nucleus → TP53BP1|​pho@Nucleus
4. E2F1:​RB1@Nucleus → E2F1:​RB1|​pho@Nucleus
5. CyclinA1*@Nucleus → degraded
6. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@Nucleus → APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@Nucleus
7. CyclinB1*@Nucleus → degraded
8. E2F4_5*:​p107*@Nucleus → E2F4_5*:​p107*|​pho@Nucleus
9. ORC4*@Nucleus + ORC5*@Nucleus + ORC6*@Nucleus + ORC3*@Nucleus + ORC2*@Nucleus + ORC1*@Nucleus → ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@Nucleus
10. MCM5@Nucleus + MCM6@Nucleus + MCM7@Nucleus + MCM2@Nucleus + MCM3@Nucleus + MCM4@Nucleus → MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@Nucleus
11. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@Nucleus + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@Nucleus + CDT1@Nucleus + CDC6@Nucleus + CDC45@Nucleus + POLA*@Nucleus + PRIM*@Nucleus + RPA1@Nucleus + RPA2@Nucleus + RPA3@Nucleus → CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*@Nucleus
12. Securin*|​S165_pho@Nucleus → degraded
13. Securin*:​Separin*@Nucleus → Securin*@Nucleus + Separin*@Nucleus
14. SCC1*:​SMC1*:​SMC3:​STAG*@Nucleus → STAG*@Nucleus + SCC1*@Nucleus + SMC3@Nucleus + SMC1*@Nucleus