→ AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*|pho|pho|pho:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*|T1479_pho|S1490_pho|T1493_pho|S1496_pho:PRR*:WNT*:_beta_-Arrestin2*:p120*@Endosome Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_CANONICAL
References
PMID:20229235 PMID:18077588 PMID:20059949 PMID:20627573
ANNOTATION:GSK3 phosphorylates first LRP @ S1490 followed by CK1 in the repeat PPSP A
ANNOTATION:CYCLINY/PFTK complex is able to phosphorylate s1490 on LRP6 which primes the receptor for CK1 phosphorylisation. The complex is present during G2/M phase and stimulates wnt signalling it has synergetic effect together with the wnt ligand
WNT/b-catenin signalling oscillates durring cell cycle and peaks at G2/M