Complex CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*
Complex composition:
- CRIPTO-1*
- LRP5_6*
- FZD*
- WNT*
- E-Cadherin*
- G_alpha_o*
- G_beta_*
- G_gamma_*
- GTP
CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
Identifiers
NAME:CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*
Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ WNT_CANONICAL
References
s_wca2_re72( Survival
):
Upon WNT3a CRIPTO-1 binds to LRP5/6 this binding is competing with DKK binding
PMID:23022962
s_wca2_re71( Survival
):
Binding of CRIPTO-1 to LRP5/6 enhances Topflash activity
su_wca1_s_wca2_re71( Survival
):
Modifications:
Participates in complexes:
In compartment: Cytoplasm
- CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
Participates in reactions:
As Reactant or Product:- CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
→
WNT canonical pathway@Cytoplasm
- E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:WNT*@Cytoplasm
+ CRIPTO-1*:LRP5_6*@Cytoplasm
→
CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT*@Cytoplasm
As Catalyser: