Simple molecule ATP map
ATP@T_cell

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map

ATP@default

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map

ATP@Extracellular space

References
em_emtc_emtc_re122( EMT Senescence  map ):
PMID:12809600
PMID:22710166
The active ligand???receptor complex is a heterotetrameric complex
This complex consists of an active dimer of TGFB and homodimers of both TGFBRI and TGFBR2.
Within the active receptor complex, TGFBR2 autophosphorylates itself and catalyzes transphosphorylation of the TGFBR1.
Transphosphorylation of the TGFBRI activates its kinase activity.

ATP@Mitochondrial Matrix

Identifiers
CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / FERROPTOSIS  map
 Regulated Cell Death  map  / FATTY_ACID_BIOSYNTHESIS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map

References
PMID:27048822
PMID:26653790
PMID:26794443
ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis.
Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis
rc_re1257:( Regulated Cell Death  map ) PMID:20823910

ATP@Mitochondrial intermembrane space

Identifiers
CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5

References
rc_re1257:( Regulated Cell Death  map ) PMID:20823910

ATP@Endopasmic Reticulum

Identifiers
CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5

ATP@Mitochondrial inner membrane

Identifiers
CHEBI:15422 KEGGCOMPOUND:C00002 CAS:56-65-5

References
rc_re2382:( Regulated Cell Death  map ) PMID:20823910

ATP@INNATE_IMMUNE_CELL_Cytosol

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map

References
 DENDRITIC_CELL  map
 MACROPHAGE  map
CASCADE:STING
CASCADE::P2RX7
CASCADE::P2RY2
PMID:20086177
ATP was released by tumor cells succumbing to chemotherapy. ATP activates purinergic P2RX7 receptors on DC, thus activating the NLRP3/ASC/caspase-1 inflammasome and driving the secretion of interleukin-1beta (IL-1beta). IL-1beta then is required for the adequate polarization of IFNgamma-producing CD8(+) T cells.
PMID:19741708
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance.
UTP and ATP act via P2RY2 and promote P2Y(2)-dependent recruitment of phagocytes, and provide evidence for a clear relationship between a find-me signal and efficient corpse clearance in vivo.
in_re1145( Innate Immunity  map ):
PMID:7890616
Intracellular Ca2+??release induces cAMP Accumulation in Human Monocytes and activation of PKA signaling downstream of IL13.

Modifications:
In compartment: Cytoplasm
  1. ATP@Cytoplasm map
In compartment: Cytosol
  1. ATP@Cytosol map
In compartment: Endopasmic Reticulum
  1. ATP@Endopasmic Reticulum map
In compartment: Extracellular space
  1. ATP@Extracellular space map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ATP@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Mitochondrial Matrix
  1. ATP@Mitochondrial Matrix map
In compartment: Mitochondrial inner membrane
  1. ATP@Mitochondrial inner membrane map
In compartment: Mitochondrial intermembrane space
  1. ATP@Mitochondrial intermembrane space map
In compartment: T_cell
  1. ATP@T_cell map
In compartment: default
  1. ATP@default map
Participates in complexes:
In compartment: Cytosol
  1. ATP:​MT-ND4L@Cytosol map
  2. ATP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map
In compartment: Endopasmic Reticulum
  1. NDUFS8:​NPL4*:​UFD1*:​p97*@Endopasmic Reticulum map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. ATP:​P2RX7@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. ATP@T_cell map → map cAMP@T_cell map
  2. ATP@default map → map AMP@default map
  3. TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol map + ATP@Extracellular space map → map TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol map + ADP@Extracellular space map
  4. SARA*:​SMAD2@Early Endosome map + ATP@Cytosol map → map SARA*:​SMAD2|​S467_pho|​S465_pho@Early Endosome map + ADP@Cytosol map
  5. SARA*:​SMAD3@Early Endosome map + ATP@Cytosol map → map SARA*:​SMAD3|​S423_pho|​S425_pho@Early Endosome map + ADP@Cytosol map
  6. Occludin*:​PARD6A:​TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol map + ATP@Cytosol map → map Occludin*:​PARD6A|​S345_pho:​TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol map + ADP@Cytosol map
  7. RAF1|​closed@Cytosol map + ATP@Cytosol map → map RAF1|​S_pho|​closed@Cytosol map + ADP@Cytosol map
  8. HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​open:​YWHAB@Cytosol map + ATP@Cytosol map → map RAF1|​S259_pho|​S621_pho|​Y340_pho|​Y341_pho|​open@Cytosol map + ADP@Cytosol map
  9. MEK1*@Cytosol map + ATP@Cytosol map → map MEK1*|​S218_pho|​S222_pho|​active@Cytosol map + ADP@Cytosol map
  10. MEK2*@Cytosol map + ATP@Cytosol map → map MEK2*|​S_pho|​active@Cytosol map + ADP@Cytosol map
  11. MKNK1@Cytosol map + ATP@Cytosol map → map MKNK1|​pho@Cytosol map + ADP@Cytosol map
  12. MKNK2@Cytosol map + ATP@Cytosol map → map MKNK2|​pho@Cytosol map + ADP@Cytosol map
  13. Occludin*@Cytosol map + ATP@Cytosol map → map Occludin*|​pho@Cytosol map + ADP@Cytosol map
  14. GJB1@Cytosol map + ATP@Cytosol map → map GJB1|​pho@Cytosol map + ADP@Cytosol map
  15. GJA3@Cytosol map + ATP@Cytosol map → map GJA3|​pho@Cytosol map + ADP@Cytosol map
  16. GJA1@Cytosol map + ATP@Cytosol map → map GJA1|​pho@Cytosol map + ADP@Cytosol map
  17. Claudin1_2_3_4*@Cytosol map + ATP@Cytosol map → map Claudin1_2_3_4*|​pho@Cytosol map + ADP@Cytosol map
  18. RAF1|​S_pho|​closed@Cytosol map + ATP@Cytosol map → map RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytosol map + ADP@Cytosol map
  19. ATP@INNATE_IMMUNE_CELL_Cytosol map → map cAMP@INNATE_IMMUNE_CELL_Cytosol map
  20. ATP@INNATE_IMMUNE_CELL_Cytosol map → map cGAMP@INNATE_IMMUNE_CELL_Cytosol map
  21. FIND_ME@TUMOR_CELL_AS_INDUCTOR map → map ATP@default map
  22. ATP@default map + P2RX7@INNATE_IMMUNE_CELL_Membrane map → map ATP:​P2RX7@INNATE_IMMUNE_CELL_Membrane map
  23. L-cysteine@Cytosol map + L-glutamate@Cytosol map + ATP@Cytosol map → map L-_gamma_-glutamyl-L-cysteine@Cytosol map + ADP@Cytosol map
  24. L-_gamma_-glutamyl-L-cysteine@Cytosol map + glycine@Cytosol map + ATP@Cytosol map → map GSH@Cytosol map + ADP@Cytosol map
  25. acetate@Mitochondrial Matrix map + ATP@Mitochondrial Matrix map + coenzyme A@Mitochondrial Matrix map → map acetyl-CoA@Mitochondrial Matrix map + AMP@Mitochondrial Matrix map
  26. acetate@Cytosol map + ATP@Cytosol map + coenzyme A@Cytosol map → map acetyl-CoA@Cytosol map + AMP@Cytosol map
  27. purine 2'-deoxyribonucleoside 5'-diphosphate@Cytosol map + ATP@Cytosol map → map purine 2'-deoxyribonucleoside 5'-triphosphate@Cytosol map + ADP@Cytosol map
  28. purine ribonucleoside 5'-diphosphate@Cytosol map + ATP@Cytosol map → map purine ribonucleoside 5'-triphosphate@Cytosol map + ADP@Cytosol map
  29. GTP@Cytosol map + ATP@Cytosol map + UTP@Cytosol map + CTP@Cytosol map → map rRNA@Cytosol map
  30. ADP@Cytosol map → map ATP@Cytosol map + AMP@Mitochondrial inner membrane map
  31. ATP@Mitochondrial Matrix map + ADP@Mitochondrial intermembrane space map → map ATP@Mitochondrial intermembrane space map + ADP@Mitochondrial Matrix map
  32. ATP@Cytosol map → map (d)ATP@Cytosol map
  33. FMN@TNFRSF1 Receptor Complex map + ATP@Cytosol map → map FAD@TNFRSF1 Receptor Complex map
  34. riboflavin@Cytosol map + ATP@Cytosol map → map FMN@TNFRSF1 Receptor Complex map
  35. ATP@Mitochondrial inner membrane map + ADP@Cytosol map → map ATP@Cytosol map + ADP@Mitochondrial inner membrane map
  36. Sphingosine@Cytosol map + ATP@Cytosol map → map Sphingosine-1-P@Cytosol map + ADP@Cytosol map
  37. purine ribonucleoside 5'-triphosphate@Cytosol map → map GTP@Cytosol map + ATP@Cytosol map
  38. GCN2*@Cytosol map + ATP@Cytosol map → map ATP:​MT-ND4L@Cytosol map
  39. ATP@Endopasmic Reticulum map + NDUFS2:​NDUFV2:​NPL4*@Endopasmic Reticulum map → map NDUFS8:​NPL4*:​UFD1*:​p97*@Endopasmic Reticulum map
  40. Methionine@Cytosol map + ATP@Cytosol map → map S-Ad??nosylm??thionine@Cytosol map + PPi@Cytosol map
  41. L-cysteine@Cytosol map + tRNACys@Cytosol map + ATP@Cytosol map → map Cys-tRNA(Cys)@Cytosol map + diphosphate@Cytosol map + AMP@Cytosol map
  42. ATP@Mitochondrial inner membrane map + ADP@Cytosol map → map ATP@Cytosol map + ADP@Mitochondrial inner membrane map
  43. glucose@Cytosol map + ATP@Cytosol map → map glucose-6P@Cytosol map + ADP@Cytosol map
  44. fructose-6P@Cytosol map + ATP@Cytosol map → map fructose-1,6P2@Cytosol map + ADP@Cytosol map
  45. fructose-6P@Cytosol map + ATP@Cytosol map → map fructose-2,6P2@Cytosol map + ADP@Cytosol map
  46. glycerate-1,3P2@Cytosol map + ADP@Cytosol map → map glycerate-3P@Cytosol map + ATP@Cytosol map
  47. phosphoenolpyruvate@Cytosol map + ADP@Cytosol map → map pyruvate@Cytosol map + ATP@Cytosol map
  48. citrate@Cytosol map + ATP@Cytosol map + coenzyme A@Cytosol map → map acetyl-CoA@Cytosol map + oxaloacetate@Cytosol map + ADP@Cytosol map
  49. acetyl-CoA@Cytosol map + NADPH@Cytosol map + ATP@Cytosol map + HCO3-@Cytosol map → map long-chain fatty acid@Cytosol map + NADP_super_+_endsuper_@Cytosol map + CO_sub_2_endsub_@Cytosol map + coenzyme A@Cytosol map + ADP@Cytosol map
  50. ACLY@Cytosol map + ATP@Cytosol map → map ACLY|​S454_pho@Cytosol map + ADP@Cytosol map
  51. ATP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map + AMP@Cytosol map → map AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map + ATP@Cytosol map
  52. PRKAA*@Cytosol map + PKA_R*@Cytosol map + PRKAG*@Cytosol map + ATP@Cytosol map → map ATP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map
  53. ACO2|​oxidized@Mitochondrial Matrix map + ATP@Mitochondrial Matrix map → map degraded + ADP@Mitochondrial Matrix map
  54. DLAT|​lipoylated:​DLD:​FAD:​PDHA*:​thiamine diphosphate@Mitochondrial Matrix map + ATP@Mitochondrial Matrix map → map DLAT|​lipoylated:​DLD:​FAD:​PDHA*|​pho:​thiamine diphosphate@Mitochondrial Matrix map + ADP@Mitochondrial Matrix map
  55. ribose-5P@Cytosol map + ATP@Cytosol map → map PRPP@Cytosol map + AMP@Cytosol map
  56. L-glutamate@Cytosol map + ATP@Cytosol map + NH3@Cytosol map → map L-glutamine@Cytosol map + ADP@Cytosol map
  57. PRDX3|​-SO2H@Mitochondrial Matrix map + ATP@Mitochondrial Matrix map → map PRDX3|​-SOH@Mitochondrial Matrix map + ADP@Mitochondrial Matrix map
  58. PRDX*|​-SO2H@Cytosol map + ATP@Cytosol map → map PRDX*|​-SOH@Cytosol map + ADP@Cytosol map
  59. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + COX4I2@Mitochondrial inner membrane map + ATP@Mitochondrial Matrix map → map COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + ADP@Mitochondrial Matrix map
  60. H+@Mitochondrial intermembrane space map + ADP@Mitochondrial Matrix map → map H+@Mitochondrial Matrix map + ATP@Mitochondrial Matrix map
  61. H+@Mitochondrial Matrix map + ATP@Mitochondrial Matrix map → map H+@Mitochondrial intermembrane space map + ADP@Mitochondrial Matrix map
  62. ATP@Cytoplasm map → map cAMP@Cytoplasm map
As Catalyser:
  1. P2RY2@INNATE_IMMUNE_CELL_Membrane map → map P2RY2@INNATE_IMMUNE_CELL_Membrane map
  2. Caspase1*:​NLRP3:​PYCARD@INNATE_IMMUNE_CELL_Cytosol map → map (NLRP3:​PYCARD:​cleaved Caspase1*)|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. EIF2S1@Cytosol map → map EIF2S1|​Ser51_pho@Cytosol map
  4. Unfolded protein*|​ubi@Endopasmic Reticulum map → map Unfolded protein*|​ubi@Cytosol map