Reaction state_transition em_emtc_emtc_re122 map

TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol map + ATP@Extracellular space map → TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Cytosol map + ADP@Extracellular space map

Reaction regulators:
Catalysis
  1. TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytosol map


Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:12809600
PMID:22710166
The active ligand???receptor complex is a heterotetrameric complex
This complex consists of an active dimer of TGFB and homodimers of both TGFBRI and TGFBR2.
Within the active receptor complex, TGFBR2 autophosphorylates itself and catalyzes transphosphorylation of the TGFBR1.
Transphosphorylation of the TGFBRI activates its kinase activity.