Complex SARA*:SMAD3 map
Complex composition:

  1. SMAD3 map
  2. SARA* map

SARA*:​SMAD3|​S423_pho|​S425_pho@Early Endosome

Identifiers
NAME:SARA*:SMAD3

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
em_emtc_emtc_re222( EMT Senescence  map ):
PMID:9311995
Smad2 and Smad3 interacted with TGFBR1 after it was phosphorylated by TGFBR2
TGFB1 induced phosphorylation of Smad2 and Smad3
em_emtc_emtc_re223( EMT Senescence  map ):
PMID:9865696
Phosphorylation of Smad2 induces dissociation from SARA
with concomitant formation of Smad2/ Smad4 complexes
and nuclear translocation.

SARA*:​SMAD3@Early Endosome

Identifiers
NAME:SARA*:SMAD3

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
em_emtc_emtc_re221( EMT Senescence  map ):
PMID:9865696
SARA interacts directly with Smad2 and Smad3
em_emtc_emtc_re222( EMT Senescence  map ):
PMID:9311995
Smad2 and Smad3 interacted with TGFBR1 after it was phosphorylated by TGFBR2
TGFB1 induced phosphorylation of Smad2 and Smad3

Modifications:
Participates in complexes:
In compartment: Early Endosome
  1. SARA*:​SMAD3@Early Endosome map
  2. SARA*:​SMAD3|​S423_pho|​S425_pho@Early Endosome map
Participates in reactions:
As Reactant or Product:
  1. SMAD3@Cytosol map + SARA*@Early Endosome map → map SARA*:​SMAD3@Early Endosome map
  2. SARA*:​SMAD3@Early Endosome map + ATP@Cytosol map → map SARA*:​SMAD3|​S423_pho|​S425_pho@Early Endosome map + ADP@Cytosol map
  3. SARA*:​SMAD3|​S423_pho|​S425_pho@Early Endosome map → map SARA*@Early Endosome map + SMAD3|​S423_pho|​S425_pho@Cytosol map
As Catalyser: