Identifiers
Claudin1_2_3_4*
claudin 1
HUGO:CLDN1, HGNC:2032, ENTREZ:9076, UNIPROT:O95832, GENECARDS:GC03M190023
claudin 2
HUGO:CLDN2, HGNC:2041, ENTREZ:9075, UNIPROT:P57739, GENECARDS:GC0XP106163
Claudin 3
HUGO:CLDN3, HGNC:2045, ENTREZ:1365, GENECARDS:GC07M073183, UNIPROT:O15551
Claudin 4
HUGO:CLDN4, HGNC:2046, ENTREZ:1364, UNIPROT:O14493, GENECARDS:GC07P073213??
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / TIGHT_JUNCTIONS
References
em_emtc_emtc_re483( EMT Senescence ):
PMID:15070779
WNK4 binds and phosphorylates claudins 1???4.
Claudins 1???4 are known to be involved in the regulation of paracellular ion permeability.
The increases in phosphorylation of claudins were greater in cells expressing the mutant WNK4 than in cells expressing wild-type protein.
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.
So the phosphorylation of Claudins 1-4 by WNK4 involves in the regulation of paracellular ion permeability
References
em_emtc_emtc_re483( EMT Senescence ):
PMID:15070779
WNK4 binds and phosphorylates claudins 1???4.
Claudins 1???4 are known to be involved in the regulation of paracellular ion permeability.
The increases in phosphorylation of claudins were greater in cells expressing the mutant WNK4 than in cells expressing wild-type protein.
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.
So the phosphorylation of Claudins 1-4 by WNK4 involves in the regulation of paracellular ion permeability
+ ATP@Cytosol → Claudin1_2_3_4*|pho@Cytosol + ADP@Cytosol
→ Claudin1*@Cytosol
→ Claudin2*@Cytosol
→ Claudin3*@Cytosol
→ Claudin4*@Cytosol