Reaction state_transition em_emtc_emtc_re222 map

SARA*:​SMAD3@Early Endosome map + ATP@Cytosol map → SARA*:​SMAD3|​S423_pho|​S425_pho@Early Endosome map + ADP@Cytosol map

Reaction regulators:
Catalysis
  1. SARA*:​TGFB1|​hm2:​TGFBR1|​Ser_pho|​hm2:​TGFBR2|​Ser_pho|​hm2@Early Endosome map


Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:9311995
Smad2 and Smad3 interacted with TGFBR1 after it was phosphorylated by TGFBR2
TGFB1 induced phosphorylation of Smad2 and Smad3