Identifiers
NAME:Occludin*:PARD6A:TGFB1:TGFBR1:TGFBR2
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / TIGHT_JUNCTIONS
References
PMID:15761153
Occludin is a structural component of tight junctions that is associated with the cell polarity network.
Occludin regulates TGFBR1 localization for efficient TGFB-dependent dissolution of tight junctions during EMT
Interaction of endogenous OCLN with endogenous TGFBR1 was not modulated by TGFB
but its association with the TGFBR2 increased in a TGFB-dependent manner
PMID:15761148
TGFBR1 localizes with ZO-1 on the cellular apical aspect together with PARD6A and they are situated apically to endogenous E-cadherin
After stimulation by TGFB, TGFBR2 is redistributed to the tight junctions, where it localizes with both TGFBR1 and ZO-1.
em_emtc_emtc_re341( EMT Senescence ):
Active TGFBR2 recruited to TIGHT_JUNCTIONS phosphorylates PARD6A on Serine residue S345 and it also phosphorylates TGFBR1
Once phosphorylated by TGFBR2, both TGFBR1 and PARD6A become active
Identifiers
NAME:Occludin*:PARD6A:TGFB1:TGFBR1:TGFBR2
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_CELL_ADHESIONS
EMT Senescence / TIGHT_JUNCTIONS
References
PMID:15761148
After stimulation by TGFB, TGFBR2 is redistributed to the tight junctions, where it localizes with both TGFBR1 and ZO-1.
Active TGFBR2 recruited to TIGHT_JUNCTIONS phosphorylates PARD6A on Serine residue S345 and it also phosphorylates TGFBR1
Once phosphorylated by TGFBR2, both TGFBR1 and PARD6A become active
+ ATP@Cytosol → Occludin*:PARD6A|S345_pho:TGFB1|hm2:TGFBR1|Ser_pho|hm2:TGFBR2|Ser_pho|hm2@Cytosol + ADP@Cytosol
+ TGFB1|hm2:TGFBR1|hm2:TGFBR2|hm2@Cytosol → Occludin*:PARD6A:TGFB1|hm2:TGFBR1|hm2:TGFBR2|hm2@Cytosol