Protein GJB1 map

Identifiers
gap junction protein, beta 1, 32kDa
HUGO:GJB1, HGNC:4283, ENTREZ:2705, UNIPROT:P08034, GENECARDS:GC0XP070435 ??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / GAP_JUNCTIONS  map

References
GJB1 is so-called Connexin 32 or Cx32
PMID:9592087
Cx32 (GJB1) interacts with Cx26(GJB2), Cx46(GJA3), and Cx50(GJA8) but failing to do so with Cx40(GJA5).
PMID:15782139
Cx32 has a strong tumor-suppressive effect on a human metastatic renal cell carcinoma cell line.
Cx32-dependent inactivation of Src decreased the production of VEGF via the suppression of Stat3 activation
PMID:11978007
Cx32 Formation and / or Cx32-Mediated Intercellular Communication Induces Expression and Function of Tight Junctions in Hepatocytic Cell Line
PMID:19284610
Cx32, colocalizes with tight junction proteins ZO-1 and ZO-2 in rat hepatocytes, and small gap junction plaques were found within tight junction strands.
It was suggested that Cx32 can participate in the formation of functional tight junctions and in actin organization.

GJB1@Cytosol

References
em_emtc_emtc_re534( EMT Senescence  map ):
GJB1 is so-called Connexin 32 or Cx32
PMID:9592087
Cx32 (GJB1) interacts with Cx26(GJB2), Cx46(GJA3), and Cx50(GJA8) but failing to do so with Cx40(GJA5).
em_emtc_emtc_re548( EMT Senescence  map ):
PMID:15782139
Cx32 has a strong tumor-suppressive effect on a human metastatic renal cell carcinoma cell line.
Cx32-dependent inactivation of Src decreased the production of VEGF via the suppression of Stat3 activation
em_emtc_emtc_re651( EMT Senescence  map ):
PMID:11978007
Cx32 Formation and / or Cx32-Mediated Intercellular Communication Induces Expression and Function of Tight Junctions in Hepatocytic Cell Line
PMID:10581193
Induction of tight junctions in human connexin 32-transfected mouse hepatocytes: connexin 32 interacts with occludin.
PMID:17568974
Connexins induce and maintain tight junctions in epithelial cells.
em_emtc_emtc_re654( EMT Senescence  map ):
PMID:19284610
Cx32, colocalizes with tight junction proteins ZO-1 and ZO-2 in rat hepatocytes, and small gap junction plaques were found within tight junction strands.
It was suggested that Cx32 can participate in the formation of functional tight junctions and in actin organization.

Modifications:
In compartment: Cytosol
  1. GJB1@Cytosol map
  2. GJB1|​pho@Cytosol map
In compartment: Neighbouring Cell
  1. GJB1@Neighbouring Cell map
Participates in complexes:
In compartment: Cytosol
  1. GJB1:​ZO1_2*@Cytosol map
  2. GJB1:​v-SRC*@Cytosol map
  3. GJB1:​Occludin*@Cytosol map
In compartment: Neighbouring Cell
  1. GJA3_8_GJB1_GJB2*:​GJB1@Neighbouring Cell map
Participates in reactions:
As Reactant or Product:
  1. GJB1@Cytosol map + ATP@Cytosol map → map GJB1|​pho@Cytosol map + ADP@Cytosol map
  2. GJA3_8_GJB1_GJB2*@Neighbouring Cell map + GJB1@Cytosol map → map GJA3_8_GJB1_GJB2*:​GJB1@Neighbouring Cell map
  3. GJB1@Cytosol map + v-SRC*@Cytosol map → map GJB1:​v-SRC*@Cytosol map
  4. GJA3_8_GJB1_GJB2*@Neighbouring Cell map → map GJB1@Neighbouring Cell map
  5. GJA3_8_GJB1_GJB2*:​GJB1@Neighbouring Cell map → map Gap junctions@Cytosol map
  6. Occludin*@Cytosol map + GJB1@Cytosol map → map GJB1:​Occludin*@Cytosol map
  7. GJB1:​Occludin*@Cytosol map → map Tight junctions@Neighbouring Cell map
  8. ZO1_2*@Cytosol map + GJB1@Cytosol map → map GJB1:​ZO1_2*@Cytosol map
  9. GJB1:​ZO1_2*@Cytosol map → map Tight junctions@Neighbouring Cell map
As Catalyser: