Simple molecule coenzyme A map
coenzyme A@Mitochondrial Matrix

Identifiers
CHEBI:15346 KEGGCOMPOUND:C00010

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / FERROPTOSIS  map
 Regulated Cell Death  map  / FATTY_ACID_BIOSYNTHESIS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map

References
PMID:27048822
PMID:26653790
PMID:26794443
ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis.
Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis

coenzyme A@Mitochondrial intermembrane space

Identifiers
CHEBI:15346 KEGGCOMPOUND:C00010

References
charge:0
85-61-0
rc_re824( Regulated Cell Death  map ):
PMID:16839620
review heme biosynthesis in mammals

coenzyme A@Cytosol

Identifiers
CHEBI:15346 KEGGCOMPOUND:C00010

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / FERROPTOSIS  map

References
PMID:27048822
PMID:26653790
PMID:26794443
ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis.
Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis

Modifications:
In compartment: Cytosol
  1. coenzyme A@Cytosol map
In compartment: Mitochondrial Matrix
  1. coenzyme A@Mitochondrial Matrix map
In compartment: Mitochondrial intermembrane space
  1. coenzyme A@Mitochondrial intermembrane space map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. acetate@Mitochondrial Matrix map + ATP@Mitochondrial Matrix map + coenzyme A@Mitochondrial Matrix map → map acetyl-CoA@Mitochondrial Matrix map + AMP@Mitochondrial Matrix map
    2. acetate@Cytosol map + ATP@Cytosol map + coenzyme A@Cytosol map → map acetyl-CoA@Cytosol map + AMP@Cytosol map
    3. citrate@Cytosol map + ATP@Cytosol map + coenzyme A@Cytosol map → map acetyl-CoA@Cytosol map + oxaloacetate@Cytosol map + ADP@Cytosol map
    4. acetyl-CoA@Cytosol map + NADPH@Cytosol map + ATP@Cytosol map + HCO3-@Cytosol map → map long-chain fatty acid@Cytosol map + NADP_super_+_endsuper_@Cytosol map + CO_sub_2_endsub_@Cytosol map + coenzyme A@Cytosol map + ADP@Cytosol map
    5. oxaloacetate@Mitochondrial Matrix map + acetyl-CoA@Mitochondrial Matrix map → map citrate@Mitochondrial Matrix map + coenzyme A@Mitochondrial Matrix map
    6. 2-oxoglutarate@Mitochondrial Matrix map + coenzyme A@Mitochondrial Matrix map + NAD_super_+_endsuper_@Mitochondrial Matrix map → map succinyl-CoA@Mitochondrial Matrix map + H+@Mitochondrial Matrix map + CO_sub_2_endsub_@Mitochondrial Matrix map + NADH@Mitochondrial Matrix map
    7. succinyl-CoA@Mitochondrial Matrix map + GDP@Mitochondrial Matrix map → map succinate@Mitochondrial Matrix map + coenzyme A@Mitochondrial Matrix map + GTP@Mitochondrial Matrix map
    8. pyruvate@Mitochondrial Matrix map + coenzyme A@Mitochondrial Matrix map + NAD_super_+_endsuper_@Mitochondrial Matrix map → map acetyl-CoA@Mitochondrial Matrix map + NADH@Mitochondrial Matrix map + CO_sub_2_endsub_@Mitochondrial Matrix map + H+@Mitochondrial Matrix map
    9. succinyl-CoA@Mitochondrial intermembrane space map + glycine@Mitochondrial intermembrane space map → map 5 aminolevulinic acid@Mitochondrial intermembrane space map + CO_sub_2_endsub_@Mitochondrial intermembrane space map + coenzyme A@Mitochondrial intermembrane space map
    As Catalyser: