+ COX4I2@Mitochondrial inner membrane + ATP@Mitochondrial Matrix → COX4I2:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a@Mitochondrial inner membrane + ADP@Mitochondrial Matrix References
PMID:17418790
Upon hypoxia, COX4I1 degraded by LONP1 is replaced into the COX complex by COX4I2, resulting in lower ROS generation and higher electron transport chain activity