Reaction state_transition em_emtc_emtc_re389 map

MEK2*@Cytosol map + ATP@Cytosol map → MEK2*|​S_pho|​active@Cytosol map + ADP@Cytosol map

Reaction regulators:
Catalysis
  1. RAF1|​S259_pho|​S621_pho|​Y340_pho|​Y341_pho|​S338_pho|​active|​open@Cytosol map


References
PMID:7565670
Active Raf-1 phosphorylates MEK-1/2 on Serine residues, converting ATP to ADP. The MEK-1/2 kinase is now active.