Complex COX4I1:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a map
Complex composition:

  1. COX4I1 map
  2. MT-CO1 map
  3. MT-CO2 map
  4. MT-CO3 map
  5. COX5A map
  6. COX5B map
  7. COX6C map
  8. COX6B* map
  9. COX7A* map
  10. COX7B* map
  11. COX7C map
  12. COX8* map
  13. heme a map
  14. Cu2+ map
  15. COX6A* map

COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane

Identifiers
NAME:COX4I1:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a

References
stoechiometry:FALSE
rc_re93( Regulated Cell Death  map ):
PMID:15119951
SURF1 mutations are associated with Leigh syndrome (cytochrome oxidase deficiency)
PMID:11389896
SURF1 Homolog of Yeast (Shy) is necessary for COX assembly and stability
PMID:19625251
Paroccocus denitrificans SURF1 homologs were proposed to promote heme a insertion into COX subunit 1
rc_re90( Regulated Cell Death  map ):
PMID:8194600
cytochrome oxidase inhibition by nitric oxide
rc_re91( Regulated Cell Death  map ):
PMID:16051147
in mice p66Shc couples O2 reduction to CYCS oxidation
rc_re92( Regulated Cell Death  map ):
PMID:17418790
Upon hypoxia, COX4I1 degraded by LONP1 is replaced into the COX complex by COX4I2, resulting in lower ROS generation and higher electron transport chain activity

Modifications:
Participates in complexes:
In compartment: Mitochondrial inner membrane
  1. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + COX4I2@Mitochondrial inner membrane map + ATP@Mitochondrial Matrix map → map COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + ADP@Mitochondrial Matrix map
  2. degraded + MT-CO1@Mitochondrial inner membrane map + COX5A@Mitochondrial inner membrane map + COX6A*@Mitochondrial inner membrane map + COX5B@Mitochondrial inner membrane map + COX7A*@Mitochondrial inner membrane map + heme a@Mitochondrial intermembrane space map + MT-CO3@Mitochondrial inner membrane map + Cu2+:​MT-CO2@Mitochondrial inner membrane map → map COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map
As Catalyser:
  1. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial Matrix map + O_sub_2_endsub_@Mitochondrial inner membrane map → map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial intermembrane space map
  2. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + O_sub_2_endsub_@Mitochondrial intermembrane space map → map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map