Protein Unfolded protein* map

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ER_STRESS  map

References
PMID:23850759
PMID:12847084
PMID:19509052
Translocated proteins also undergo modifications to support folding; these include N-terminal glycosylation and disulphide bond formation

Modifications:
In compartment: Cytosol
  1. Unfolded protein*@Cytosol map
  2. Unfolded protein*|​ubi@Cytosol map
In compartment: Endopasmic Reticulum
  1. Unfolded protein*@Endopasmic Reticulum map
  2. Unfolded protein*|​ubi@Endopasmic Reticulum map
  3. Unfolded protein*|​gly|​disulphide bond_unk@Endopasmic Reticulum map
In compartment: Proteasome
  1. Unfolded protein*@Proteasome map
  2. Unfolded protein*|​ubi@Proteasome map
Participates in complexes:
In compartment: Endopasmic Reticulum
  1. IRE1-alpha*:​Unfolded protein*@Endopasmic Reticulum map
  2. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map
Participates in reactions:
As Reactant or Product:
  1. IRE1-alpha*@Endopasmic Reticulum map + Unfolded protein*@Endopasmic Reticulum map → map IRE1-alpha*:​Unfolded protein*@Endopasmic Reticulum map
  2. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map → map mRNA translation@Cytosol map
  3. IRE1-alpha*:​Unfolded protein*@Endopasmic Reticulum map + TRAF2@Cytosol map → map MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map
  4. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map → map RIDD process@Cytosol map
  5. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map → map RIDD process@Cytosol map
  6. accumulation of misfolded protein in ER@Endopasmic Reticulum map → map Unfolded protein*@Endopasmic Reticulum map
  7. Unfolded protein*@Endopasmic Reticulum map → map Unfolded protein*|​ubi@Endopasmic Reticulum map
  8. Unfolded protein*|​ubi@Endopasmic Reticulum map → map Unfolded protein*|​ubi@Cytosol map
  9. Unfolded protein*@Proteasome map → map degraded
  10. Unfolded protein*|​ubi@Cytosol map → map Unfolded protein*|​ubi@Proteasome map
  11. Unfolded protein*|​ubi@Proteasome map → map Unfolded protein*@Proteasome map
  12. Unfolded protein*|​ubi@Proteasome map → map degraded
  13. Unfolded protein*@Cytosol map → map Unfolded protein*@Endopasmic Reticulum map
  14. Unfolded protein*@Endopasmic Reticulum map → map Unfolded protein*|​gly|​disulphide bond_unk@Endopasmic Reticulum map
  15. Unfolded protein*|​gly|​disulphide bond_unk@Endopasmic Reticulum map → map Protein folding@Endopasmic Reticulum map
  16. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map → map UPR@Cytosol map
  17. MCL1|​pho|​hm2:​TRAF2:​Unfolded protein*@Endopasmic Reticulum map → map adaptative response@Cytosol map
As Catalyser:
  1. ATF6:​BiP*@Endopasmic Reticulum map → map ATF6@Endopasmic Reticulum map + BiP*@Endopasmic Reticulum map
  2. ruXBP1@Nucleus map → map rsXBP1@Nucleus map
  3. rIRE1-alpha*@Nucleus map → map rIRE1-alpha*@Nucleus map
  4. TRAF2@Cytosol map → map TRAF2@Cytosol map
  5. ASK1*@Cytosol map → map ASK1*|​pho|​active@Cytosol map
  6. PERK*@Endopasmic Reticulum map → map rc_s267
  7. CHUK:​IKBKB@Cytosol map → map CHUK:​SDHC|​pho|​pho@Cytosol map