Protein COX4I2 map

Identifiers
cytochrome c oxidase subunit IV isoform 2 (lung)
HUGO:COX4I2 HGNC:16232 ENTREZ:84701 UNIPROT:Q96KJ9

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map
 RECON2  map

COX4I2@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
rc_re92( Regulated Cell Death  map ):
PMID:17418790
Upon hypoxia, COX4I1 degraded by LONP1 is replaced into the COX complex by COX4I2, resulting in lower ROS generation and higher electron transport chain activity

Modifications:
In compartment: Mitochondrial inner membrane
  1. COX4I2@Mitochondrial inner membrane map
Participates in complexes:
In compartment: Mitochondrial inner membrane
  1. COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. rCOX4I2@Nucleus map → map COX4I2@Mitochondrial inner membrane map
  2. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + COX4I2@Mitochondrial inner membrane map + ATP@Mitochondrial Matrix map → map COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + ADP@Mitochondrial Matrix map
As Catalyser:
  1. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial Matrix map + O_sub_2_endsub_@Mitochondrial inner membrane map → map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial intermembrane space map