Simple molecule ADP
ADP@Extracellular space
References
em_emtc_emtc_re122( EMT Senescence
):
PMID:12809600
PMID:22710166
The active ligand???receptor complex is a heterotetrameric complex
This complex consists of an active dimer of TGFB and homodimers of both TGFBRI and TGFBR2.
Within the active receptor complex, TGFBR2 autophosphorylates itself and catalyzes transphosphorylation of the TGFBR1.
Transphosphorylation of the TGFBRI activates its kinase activity.
ADP@Mitochondrial Matrix
Identifiers
CHEBI:16761 KEGGCOMPOUND:C00008 CAS:58-64-0
References
rc_re981( Regulated Cell Death
):
PMID:10838049
review
rc_re1257:( Regulated Cell Death
) PMID:20823910
ADP@Mitochondrial intermembrane space
Identifiers
CHEBI:16761 KEGGCOMPOUND:C00008 CAS:58-64-0
References
rc_re1257:( Regulated Cell Death
) PMID:20823910
ADP@Mitochondrial inner membrane
Identifiers
CHEBI:16761 KEGGCOMPOUND:C00008 CAS:58-64-0
References
rc_re2382:( Regulated Cell Death
) PMID:20823910
Modifications:
In compartment: Cytosol
- ADP@Cytosol
In compartment: Extracellular space
- ADP@Extracellular space
In compartment: Mitochondrial Matrix
- ADP@Mitochondrial Matrix
In compartment: Mitochondrial inner membrane
- ADP@Mitochondrial inner membrane
In compartment: Mitochondrial intermembrane space
- ADP@Mitochondrial intermembrane space
Participates in complexes:
Participates in reactions:
As Reactant or Product:- TGFB1|hm2:TGFBR1|hm2:TGFBR2|hm2@Cytosol
+ ATP@Extracellular space
→
TGFB1|hm2:TGFBR1|Ser_pho|hm2:TGFBR2|Ser_pho|hm2@Cytosol
+ ADP@Extracellular space
- SARA*:SMAD2@Early Endosome
+ ATP@Cytosol
→
SARA*:SMAD2|S467_pho|S465_pho@Early Endosome
+ ADP@Cytosol
- SARA*:SMAD3@Early Endosome
+ ATP@Cytosol
→
SARA*:SMAD3|S423_pho|S425_pho@Early Endosome
+ ADP@Cytosol
- Occludin*:PARD6A:TGFB1|hm2:TGFBR1|hm2:TGFBR2|hm2@Cytosol
+ ATP@Cytosol
→
Occludin*:PARD6A|S345_pho:TGFB1|hm2:TGFBR1|Ser_pho|hm2:TGFBR2|Ser_pho|hm2@Cytosol
+ ADP@Cytosol
- RAF1|closed@Cytosol
+ ATP@Cytosol
→
RAF1|S_pho|closed@Cytosol
+ ADP@Cytosol
- HRAS:RAF1|S259_pho|S621_pho|S_pho|open:YWHAB@Cytosol
+ ATP@Cytosol
→
RAF1|S259_pho|S621_pho|Y340_pho|Y341_pho|open@Cytosol
+ ADP@Cytosol
- MEK1*@Cytosol
+ ATP@Cytosol
→
MEK1*|S218_pho|S222_pho|active@Cytosol
+ ADP@Cytosol
- MEK2*@Cytosol
+ ATP@Cytosol
→
MEK2*|S_pho|active@Cytosol
+ ADP@Cytosol
- MKNK1@Cytosol
+ ATP@Cytosol
→
MKNK1|pho@Cytosol
+ ADP@Cytosol
- MKNK2@Cytosol
+ ATP@Cytosol
→
MKNK2|pho@Cytosol
+ ADP@Cytosol
- Occludin*@Cytosol
+ ATP@Cytosol
→
Occludin*|pho@Cytosol
+ ADP@Cytosol
- GJB1@Cytosol
+ ATP@Cytosol
→
GJB1|pho@Cytosol
+ ADP@Cytosol
- GJA3@Cytosol
+ ATP@Cytosol
→
GJA3|pho@Cytosol
+ ADP@Cytosol
- GJA1@Cytosol
+ ATP@Cytosol
→
GJA1|pho@Cytosol
+ ADP@Cytosol
- Claudin1_2_3_4*@Cytosol
+ ATP@Cytosol
→
Claudin1_2_3_4*|pho@Cytosol
+ ADP@Cytosol
- RAF1|S_pho|closed@Cytosol
+ ATP@Cytosol
→
RAF1|S259_pho|S621_pho|S_pho|closed@Cytosol
+ ADP@Cytosol
- L-cysteine@Cytosol
+ L-glutamate@Cytosol
+ ATP@Cytosol
→
L-_gamma_-glutamyl-L-cysteine@Cytosol
+ ADP@Cytosol
- L-_gamma_-glutamyl-L-cysteine@Cytosol
+ glycine@Cytosol
+ ATP@Cytosol
→
GSH@Cytosol
+ ADP@Cytosol
- ADP@Cytosol
→
purine ribonucleoside 5'-diphosphate@Cytosol
- purine 2'-deoxyribonucleoside 5'-diphosphate@Cytosol
+ ATP@Cytosol
→
purine 2'-deoxyribonucleoside 5'-triphosphate@Cytosol
+ ADP@Cytosol
- purine ribonucleoside 5'-diphosphate@Cytosol
+ ATP@Cytosol
→
purine ribonucleoside 5'-triphosphate@Cytosol
+ ADP@Cytosol
- ADP@Cytosol
→
ATP@Cytosol
+ AMP@Mitochondrial inner membrane
- ATP@Mitochondrial Matrix
+ ADP@Mitochondrial intermembrane space
→
ATP@Mitochondrial intermembrane space
+ ADP@Mitochondrial Matrix
- ATP@Mitochondrial inner membrane
+ ADP@Cytosol
→
ATP@Cytosol
+ ADP@Mitochondrial inner membrane
- Sphingosine@Cytosol
+ ATP@Cytosol
→
Sphingosine-1-P@Cytosol
+ ADP@Cytosol
- ATP@Mitochondrial inner membrane
+ ADP@Cytosol
→
ATP@Cytosol
+ ADP@Mitochondrial inner membrane
- glucose@Cytosol
+ ATP@Cytosol
→
glucose-6P@Cytosol
+ ADP@Cytosol
- fructose-6P@Cytosol
+ ATP@Cytosol
→
fructose-1,6P2@Cytosol
+ ADP@Cytosol
- fructose-6P@Cytosol
+ ATP@Cytosol
→
fructose-2,6P2@Cytosol
+ ADP@Cytosol
- glycerate-1,3P2@Cytosol
+ ADP@Cytosol
→
glycerate-3P@Cytosol
+ ATP@Cytosol
- phosphoenolpyruvate@Cytosol
+ ADP@Cytosol
→
pyruvate@Cytosol
+ ATP@Cytosol
- citrate@Cytosol
+ ATP@Cytosol
+ coenzyme A@Cytosol
→
acetyl-CoA@Cytosol
+ oxaloacetate@Cytosol
+ ADP@Cytosol
- acetyl-CoA@Cytosol
+ NADPH@Cytosol
+ ATP@Cytosol
+ HCO3-@Cytosol
→
long-chain fatty acid@Cytosol
+ NADP_super_+_endsuper_@Cytosol
+ CO_sub_2_endsub_@Cytosol
+ coenzyme A@Cytosol
+ ADP@Cytosol
- ACLY@Cytosol
+ ATP@Cytosol
→
ACLY|S454_pho@Cytosol
+ ADP@Cytosol
- ACO2|oxidized@Mitochondrial Matrix
+ ATP@Mitochondrial Matrix
→
degraded + ADP@Mitochondrial Matrix
- DLAT|lipoylated:DLD:FAD:PDHA*:thiamine diphosphate@Mitochondrial Matrix
+ ATP@Mitochondrial Matrix
→
DLAT|lipoylated:DLD:FAD:PDHA*|pho:thiamine diphosphate@Mitochondrial Matrix
+ ADP@Mitochondrial Matrix
- L-glutamate@Cytosol
+ ATP@Cytosol
+ NH3@Cytosol
→
L-glutamine@Cytosol
+ ADP@Cytosol
- PRDX3|-SO2H@Mitochondrial Matrix
+ ATP@Mitochondrial Matrix
→
PRDX3|-SOH@Mitochondrial Matrix
+ ADP@Mitochondrial Matrix
- PRDX*|-SO2H@Cytosol
+ ATP@Cytosol
→
PRDX*|-SOH@Cytosol
+ ADP@Cytosol
- COX4I1:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a@Mitochondrial inner membrane
+ COX4I2@Mitochondrial inner membrane
+ ATP@Mitochondrial Matrix
→
COX4I2:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a@Mitochondrial inner membrane
+ ADP@Mitochondrial Matrix
- H+@Mitochondrial intermembrane space
+ ADP@Mitochondrial Matrix
→
H+@Mitochondrial Matrix
+ ATP@Mitochondrial Matrix
- H+@Mitochondrial Matrix
+ ATP@Mitochondrial Matrix
→
H+@Mitochondrial intermembrane space
+ ADP@Mitochondrial Matrix
As Catalyser: