Identifiers
NAME:SARA*:SMAD2
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
em_emtc_emtc_re217( EMT Senescence ):
PMID:9311995
Smad2 and Smad3 interacted with TGFBR1 after it was phosphorylated by TGFBR2
TGFB1 induced phosphorylation of Smad2 and Smad3
em_emtc_emtc_re218( EMT Senescence ):
PMID:9865696
Phosphorylation of Smad2 induces dissociation from SARA
with concomitant formation of Smad2/ Smad4 complexes
and nuclear translocation.
Identifiers
NAME:SARA*:SMAD2
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
em_emtc_emtc_re216( EMT Senescence ):
PMID:9865696
SARA interacts directly with Smad2 and Smad3
PMID:11792802
SARA is a cytoplasmic protein that specifically interacts withe no-activated Smad2 and the receptor complex
SARA thus forms the bridge between the receptor and Smad2 and assisting in the specific phosphorylation of Smad2 by the TGFBR1
The stable interaction of SARA with non-phosphorylated Smad2 also inhibits nuclear import of Smad2
PMID:10934479
The nuclear import function of Smad2 is masked by SARA and unmasked by TGFB- dependent phosphorylation
em_emtc_emtc_re217( EMT Senescence ):
PMID:9311995
Smad2 and Smad3 interacted with TGFBR1 after it was phosphorylated by TGFBR2
TGFB1 induced phosphorylation of Smad2 and Smad3
+ SARA*@Early Endosome → SARA*:SMAD2@Early Endosome
+ ATP@Cytosol → SARA*:SMAD2|S467_pho|S465_pho@Early Endosome + ADP@Cytosol
→ SMAD2|S467_pho|S465_pho@Cytosol + SARA*@Early Endosome