ACLY

Protein ACLY

Identifiers
ATP citrate lyase
HUGO:ACLY HGNC:115 ENTREZ:47 UNIPROT:P53396

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / FATTY_ACID_BIOSYNTHESIS
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE
RECON2

ACLY@Cytosol

References
rc_re301( Regulated Cell Death ):
PMID:10653665
in vitro, S454 phosphorylation of ACLY increases its activity
PMID:12107176
in primary rat adipocytes, Akt mediated ACLY S454 phosphorylation
rc_re303( Regulated Cell Death ):
fructose 6-phosphate was found to be a potent activator (60-fold) of the unphosphorylated recombinant enzyme

ACLY|S454_pho@Cytosol

ACLY|S454_don|hm4@Cytosol

References
rc_re302:( Regulated Cell Death ) reactionType:is.a
rc_re303( Regulated Cell Death ):
PMID:10653665
fructose 6-phosphate was found to be a potent activator (60-fold) of the unphosphorylated recombinant enzyme

Modifications:
In compartment: Cytosol

ACLY@Cytosol
ACLY|S454_pho@Cytosol
ACLY|S454_don|hm4@Cytosol

Participates in complexes:

Participates in reactions:
As Reactant or Product:

As Catalyser:

citrate@Cytosol + ATP@Cytosol + coenzyme A@Cytosol → acetyl-CoA@Cytosol + oxaloacetate@Cytosol + ADP@Cytosol