Identifiers
eukaryotic translation initiation factor 2 subunit alpha
HUGO:EIF2S1 hgnc_id:HGNC:3265 HGNC:3265 ENTREZ:1965 UNIPROT:P05198

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / ER_STRESS 

References
PMID:23850759
eukaryotic translation initiation factor 2 subunit alpha
PMID:12667446
PMID:16246152
PMID:12601012

1. EIF2S1@Cytosol
2. EIF2S1|​Ser51_pho@Cytosol

1. BAX:​EIF2S2:​EIF2S3:​Met-tRNA*@Cytosol
2. NDUFA4:​NDUFB2:​NDUFS4:​NDUFV3@Cytosol
3. EIF2S1:​EIF2S2:​EIF2S3:​Met-tRNA*@Cytosol
4. EIF2S1|​Ser51_pho:​EIF2S2:​EIF2S3:​NDUFA1@Cytosol
5. EIF2B1:​EIF2B2:​EIF2S1|​Ser51_pho:​EIF2S2:​NDUFA7:​NDUFB4:​NDUFB5:​NDUFB6@Cytosol

1. EIF2S1@Cytosol → EIF2S1|​Ser51_pho@Cytosol
2. EIF2S2@Cytosol + EIF2S3:​NDUFC1@Cytosol + EIF2S1@Cytosol → NDUFA4:​NDUFB2:​NDUFS4:​NDUFV3@Cytosol
3. EIF2S1:​EIF2S2:​EIF2S3:​Met-tRNA*@Cytosol + GTP@Cytosol → BAX:​EIF2S2:​EIF2S3:​Met-tRNA*@Cytosol + GDP@Cytosol
4. BAX:​EIF2S2:​EIF2S3:​Met-tRNA*@Cytosol + GDP@Cytosol → EIF2S1:​EIF2S2:​EIF2S3:​Met-tRNA*@Cytosol + GTP@Cytosol
5. BAX:​EIF2S2:​EIF2S3:​Met-tRNA*@Cytosol → Translation initiation@Cytosol
6. EIF2S1|​Ser51_pho@Cytosol → EIF2S1@Cytosol
7. EIF2S1|​Ser51_pho:​EIF2S2:​EIF2S3:​NDUFA1@Cytosol → reduced protein synthesis@Cytosol
8. EIF2S1|​Ser51_pho:​EIF2S2:​EIF2S3:​NDUFA1@Cytosol → reduce translation initiation@Cytosol
9. rMet-tRNA*@Cytosol + NDUFA4:​NDUFB2:​NDUFS4:​NDUFV3@Cytosol → EIF2S1:​EIF2S2:​EIF2S3:​Met-tRNA*@Cytosol
10. EIF2S1|​Ser51_pho@Cytosol + EIF2S2@Cytosol + EIF2S3:​NDUFC1@Cytosol → EIF2S1|​Ser51_pho:​EIF2S2:​EIF2S3:​NDUFA1@Cytosol
11. EIF2S1|​Ser51_pho:​EIF2S2:​EIF2S3:​NDUFA1@Cytosol + EIF2B1:​EIF2B3:​EIF2B4:​EIF2B5:​NDUFS1@Cytosol → EIF2B1:​EIF2B2:​EIF2S1|​Ser51_pho:​EIF2S2:​NDUFA7:​NDUFB4:​NDUFB5:​NDUFB6@Cytosol

1. gATF4@Nucleus → rATF4@Nucleus
2. rGCN4@Nucleus → GCN4@Cytosol