Reaction state_transition em_emtc_emtc_re383 map

RAF1|​closed@Cytosol map + ATP@Cytosol map → RAF1|​S_pho|​closed@Cytosol map + ADP@Cytosol map

Reaction regulators:
Catalysis
  1. ERK2*|​T_pho|​Y_pho|​hm2|​active@Cytosol map


References
Negative feedback: MAPK1/ERK2 phosphorylates RAF1 on Ser 29, 43, 289, 296, 301, 642, generating an inactive kinase.
PIN1, a prolyl isomerase converts pSer and pThr residues from the cis to the trans conformation, which is preferentially recognized and dephosphorylated by PPP2R1A.