AMP:PKA_R*:PRKAA*:PRKAG*

Complex AMP:PKA_R*:PRKAA*:PRKAG*

Complex composition:

AMP:PKA_R*:PRKAA*:PRKAG*@Cytosol

Identifiers
NAME:AMP:PKA_R*:PRKAA*:PRKAG*

References
rc_re335( Regulated Cell Death ):
PMID:15509864
review
rc_re334( Regulated Cell Death ):
PMID:16054095
by CAMKK2
PMID:16054096
PMID:17244528
by calcium via CAMKK2 and AMPK
PMID:15980064
by CAMKK
PMID:18692468
propose that SESN2 promotes AMPK autophosphorylation, thus increasing TSC1/2 activity.
PMID:19197243
in RPE1-hTERT mouse inner medullary collecting duct cells, in MEFs, in MCF10A, by TAK1, upon TRAIL exposure
in MCF10A upon Ca2+ by CAMKK2
High Calcium lvl activate CAMKK2 enzyme and leads to AMPK activation
PMID:19037093PMID:17244528
PMID:20484410
rc_re336( Regulated Cell Death ):
PMID:8910387
by LKB1, from rat enzyme
LKB1 dependent AMPK phosphorylation induced by glucose starvation
in MCF10A upon starvation by LKB1
PMID:20160076
in EBV-immortalized B-lymphocytes from healthy individuals, but not from ATM-deficient AT patients, upon H2O2PMID:12546687
In normoxic cells, the very low AMP/ATP ratio (about 0.05) keeps AMPK mainly in the inactive form
PMID:19942859
PMID:23030059

AMP:PKA_R*:PRKAA*|T172_pho:PRKAG*@Cytosol

Identifiers
NAME:AMP:PKA_R*:PRKAA*:PRKAG*

References
PMID:12208500
PMID:23030059
PMID:12546687
PMID:19037093
rc_re334( Regulated Cell Death ):
PMID:15509864
review
PMID:16054095
by CAMKK2
PMID:16054096
PMID:17244528
by calcium via CAMKK2 and AMPK
PMID:15980064
by CAMKK
PMID:18692468
propose that SESN2 promotes AMPK autophosphorylation, thus increasing TSC1/2 activity.
PMID:19197243
in RPE1-hTERT mouse inner medullary collecting duct cells, in MEFs, in MCF10A, by TAK1, upon TRAIL exposure
in MCF10A upon Ca2+ by CAMKK2
High Calcium lvl activate CAMKK2 enzyme and leads to AMPK activation
PMID:19037093PMID:17244528
PMID:20484410
rc_re336( Regulated Cell Death ):
PMID:8910387
by LKB1, from rat enzyme
LKB1 dependent AMPK phosphorylation induced by glucose starvation
in MCF10A upon starvation by LKB1
PMID:20160076
in EBV-immortalized B-lymphocytes from healthy individuals, but not from ATM-deficient AT patients, upon H2O2PMID:12546687
In normoxic cells, the very low AMP/ATP ratio (about 0.05) keeps AMPK mainly in the inactive form
PMID:19942859
rc_re96( Regulated Cell Death ):
PMID:10508159
CASP3 cleavage by cathepsin D as data not shown
sustained activation of AMPK induces Caspase 3 cleavage and so lead to apoptosis triggering
rc_re271( Regulated Cell Death ):
PMID:16115917
phosphorylation at S461 (isoform PFKFB3-ACG) in different tumor cells
in COS-7, expression of a phosphomimetic mutant enhances glycolysis
PMID:17712357
by AMPK review
rc_re273:( Regulated Cell Death ) PMID:11069105
rc_re352( Regulated Cell Death ):
PMID:14651849
PMID:19339977
SESN2 promotes TSC2 phosphorylation, and interacts with both AMPK and TSC2.
rc_re370( Regulated Cell Death ):
PMID:18439900
in HEK293
rc_re1068( Regulated Cell Death ):
PMID:9029219
PMID:16326698
rc_re1756( Regulated Cell Death ):
PMID:23725295
PMID:22166994

Modifications:
Participates in complexes:
In compartment: Cytosol

Participates in reactions:
As Reactant or Product:

As Catalyser: