Simple molecule acetyl-CoA map
acetyl-CoA@Mitochondrial Matrix

Identifiers
CHEBI:15351 KEGGCOMPOUND:C00024 CAS:72-89-9

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / FERROPTOSIS  map
 Regulated Cell Death  map  / FATTY_ACID_BIOSYNTHESIS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map

References
PMID:27048822
PMID:26653790
PMID:26794443
ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis.
Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis
PMID:28645028

acetyl-CoA@Cytosol

Identifiers
CHEBI:15351 KEGGCOMPOUND:C00024 CAS:72-89-9

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / FERROPTOSIS  map

References
PMID:27048822
PMID:26653790
PMID:26794443
ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis.
Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis

Modifications:
In compartment: Cytosol
  1. acetyl-CoA@Cytosol map
In compartment: Mitochondrial Matrix
  1. acetyl-CoA@Mitochondrial Matrix map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. acetate@Mitochondrial Matrix map + ATP@Mitochondrial Matrix map + coenzyme A@Mitochondrial Matrix map → map acetyl-CoA@Mitochondrial Matrix map + AMP@Mitochondrial Matrix map
    2. acetate@Cytosol map + ATP@Cytosol map + coenzyme A@Cytosol map → map acetyl-CoA@Cytosol map + AMP@Cytosol map
    3. citrate@Cytosol map + ATP@Cytosol map + coenzyme A@Cytosol map → map acetyl-CoA@Cytosol map + oxaloacetate@Cytosol map + ADP@Cytosol map
    4. acetyl-CoA@Cytosol map + NADPH@Cytosol map + ATP@Cytosol map + HCO3-@Cytosol map → map long-chain fatty acid@Cytosol map + NADP_super_+_endsuper_@Cytosol map + CO_sub_2_endsub_@Cytosol map + coenzyme A@Cytosol map + ADP@Cytosol map
    5. oxaloacetate@Mitochondrial Matrix map + acetyl-CoA@Mitochondrial Matrix map → map citrate@Mitochondrial Matrix map + coenzyme A@Mitochondrial Matrix map
    6. pyruvate@Mitochondrial Matrix map + coenzyme A@Mitochondrial Matrix map + NAD_super_+_endsuper_@Mitochondrial Matrix map → map acetyl-CoA@Mitochondrial Matrix map + NADH@Mitochondrial Matrix map + CO_sub_2_endsub_@Mitochondrial Matrix map + H+@Mitochondrial Matrix map
    As Catalyser: