Protein PKA_R* map

Identifiers
protein kinase, AMP-activated, beta 1 non-catalytic subunit
HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478
protein kinase, AMP-activated, beta 2 non-catalytic subunit
HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741
HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1
HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2
HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1
HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2
HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3
HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A
HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B
HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A
HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B
protein kinase AMP-activated gamma 1 non-catalytic subunit
protein kinase AMP-activated gamma 2 non-catalytic subunit
protein kinase cAMP-dependent regulatory type I alpha
protein kinase cAMP-dependent regulatory type I beta
protein kinase cAMP-dependent regulatory type II alpha
protein kinase cAMP-dependent regulatory type II beta

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / FATTY_ACID_BIOSYNTHESIS  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
HMC:TUMOR_PROMOTING_INFLAMMATION
 Innate Immunity  map  / IMMUNOSUPPPRESSIVE_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:18501881, PMID:7890616
Intracellular Ca2+??release induces cAMP Accumulation in Human Monocytes and activation of PKA signaling downstream of IL13.
IL-13 significantly inhibits the ROS generation in all macrophage types, probably, via PLC/Ca2+/cAMP/PKA pathway

PKA_R*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / FATTY_ACID_BIOSYNTHESIS  map
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map

Modifications:
In compartment: Cytosol
  1. PKA_R*@Cytosol map
Participates in complexes:
In compartment: Cytoplasm
  1. PKA_C*:​PKA_R*@Cytoplasm map
  2. PKA_C*:​PKA_R*@Cytoplasm map
  3. (PKA_C*:​PKA_R*)|​active@Cytoplasm map
In compartment: Cytosol
  1. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map
  2. ATP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map
  3. AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PKA*:​PKA_R*@INNATE_IMMUNE_CELL_Cytosol map
  2. PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol map
  3. PKA*:​PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. (PKA_C*:​PKA_R*)|​active@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. cAMP@INNATE_IMMUNE_CELL_Cytosol map + PKA*:​PKA_R*@INNATE_IMMUNE_CELL_Cytosol map → map PKA*:​PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol map
  2. PKA*:​PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol map → map PKA_R*:​cAMP@INNATE_IMMUNE_CELL_Cytosol map + PKA*@INNATE_IMMUNE_CELL_Cytosol map
  3. rPKA_R*@Nucleus map → map PKA_R*@Cytosol map
  4. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map → map AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytosol map
  5. ATP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map + AMP@Cytosol map → map AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map + ATP@Cytosol map
  6. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map → map AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytosol map
  7. PRKAA*@Cytosol map + PKA_R*@Cytosol map + PRKAG*@Cytosol map + ATP@Cytosol map → map ATP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map
  8. p38*@Cytoplasm map → map PKA_C*:​PKA_R*@Cytoplasm map
  9. High cell density@Cytoplasm map → map PKA_C*:​PKA_R*@Cytoplasm map
  10. PKA_C*:​PKA_R*@Cytoplasm map → map PKA_C*:​PKA_R*@Cytoplasm map
As Catalyser:
  1. ACACA@Cytosol map → map ACACA|​S79_pho@Cytosol map
  2. JNK1*@Cytosol map → map JNK1*|​pho|​active@Cytosol map
  3. ULK*@Cytosol map → map ULK*|​Ser 317_pho|​Ser 777_pho@Cytosol map
  4. PFKFB3@Cytosol map → map PFKFB3|​pho@Cytosol map
  5. PFKFB2@Cytosol map → map PFKFB2|​pho@Cytosol map
  6. TSC1:​TSC2|​M1_unk@Cytosol map → map TSC1:​TSC2|​S1345_pho|​M1_unk@Cytosol map
  7. RPTOR@Cytosol map → map RPTOR|​S722_pho|​S792_pho@Cytosol map
  8. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
  9. APC@Cytoplasm map → map APC|​S2054_pho@Cytoplasm map
  10. LRP6@Cytoplasm map → map LRP6|​S1544_pho|​T1548_pho@Cytoplasm map
  11. DACT1@Cytoplasm map → map DACT1|​S237_pho|​S827_pho@Cytoplasm map
  12. _beta_-Catenin*@Cytoplasm map → map _beta_-Catenin*|​S552_pho@Cytoplasm map
  13. _beta_-Catenin*|​S552_pho@Cytoplasm map → map _beta_-Catenin*|​S552_pho|​pho@Cytoplasm map
  14. NFAT*@Nucleus map → map NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map