Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / METABOLIC 

References
PMID:22101652; PMID:19923890
The M1 or M2 splice isoforms of pyruvate kinase (PK), a mandatory regulatory glycolytic enzyme, shift glucose metabolism towards aerobic glycolysis (PKM2) or oxidative phosphorylation (PKM1)
PKM2 and lactate dehydrogenase are highly expressed in the stroma of breast cancer lacking caveolin-1 expression
CASCADE:TGFB
CASCADE:PDGF

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / METABOLIC 

References
CASCADE:TGFB
CASCADE:PDGF
PMID:25732824
CAFs have a higher capacity for glucose uptake than do fibroblasts

Identifiers
CHEBI:17634 KEGGCOMPOUND:C00031 CAS:50-99-7

References
PMID:12546687
rc_re274( Regulated Cell Death  ):
PMID:17472435
in human adipocytes and skeletal muscle cells differentiated in vitro, using RNA interference to TXNIP
PMID:18458340
in HA1ER cells (human embryonic kidney epithelial cells,express hTERT, the early region from simian virus 40, and HA H-RasG12V), knock-down of MondoA induces reduced expression of TXNIP and increased glucose uptake, which is reversed by ectopic expression of TXNIP

1. glucose@Cytosol

1. glucose@Extracellular space

1. glucose@default

1. glucose@Cytosol → Glycolysis@Cytosol
2. glucose@default → glucose@Cytosol
3. glucose@Cytosol → Glucose deprivation@Cytosol
4. glucose@Cytosol + ATP@Cytosol → glucose-6P@Cytosol + ADP@Cytosol
5. glucose@Extracellular space → glucose@Cytosol

1. AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol → AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytosol